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Role of Minimal (Measurable) Residual Disease Assessment in Older Patients with Acute Myeloid Leukemia
Review

Geriatric Assessment in Older Patients with Acute Myeloid Leukemia

1
James P. Wilmot Cancer Institute, University of Rochester Medical Center, 601 Elmwood Avenue, Box 704, Rochester, NY 14642, USA
2
Wake Forest Baptist Comprehensive Cancer Center, Medical Center Blvd, Winston-Salem, NC 27157, USA
*
Author to whom correspondence should be addressed.
Cancers 2018, 10(7), 225; https://doi.org/10.3390/cancers10070225
Received: 14 June 2018 / Revised: 3 July 2018 / Accepted: 5 July 2018 / Published: 6 July 2018
(This article belongs to the Special Issue Treatment of Older Adults with Acute Myeloid Leukemia)
The incidence of acute myeloid leukemia (AML) increases with age, but the outcomes for older adults with AML are poor due to underlying tumor biology, poor tolerance to aggressive treatment, and the physiologic changes of aging. Because of the underlying heterogeneity in health status, treatment decisions are difficult in this population. A geriatric assessment (GA) refers to the use of various validated tools to assess domains that are important in older adults including physical function, cognition, comorbidities, polypharmacy, social support, and nutritional status. In older patients with cancer, a GA can guide treatment decision-making, predict treatment toxicity, and guide supportive care interventions. Compared to solids tumors, there is a relative lack of studies evaluating the use of a GA in older patients with AML. In this review, we will discuss the principles, common domains, feasibility, and benefits of GA, with a focus on older patients with AML that includes practical applications for clinical management. View Full-Text
Keywords: comprehensive geriatric assessment; older adults; acute myeloid leukemia comprehensive geriatric assessment; older adults; acute myeloid leukemia
MDPI and ACS Style

Loh, K.P.; Klepin, H.D. Geriatric Assessment in Older Patients with Acute Myeloid Leukemia. Cancers 2018, 10, 225. https://doi.org/10.3390/cancers10070225

AMA Style

Loh KP, Klepin HD. Geriatric Assessment in Older Patients with Acute Myeloid Leukemia. Cancers. 2018; 10(7):225. https://doi.org/10.3390/cancers10070225

Chicago/Turabian Style

Loh, Kah P.; Klepin, Heidi D. 2018. "Geriatric Assessment in Older Patients with Acute Myeloid Leukemia" Cancers 10, no. 7: 225. https://doi.org/10.3390/cancers10070225

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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