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Lysophospholipid Signaling in the Epithelial Ovarian Cancer Tumor Microenvironment

Department of Obstetrics and Gynecology, Indiana University School of Medicine, 1044W. Walnut Street R4-W037, Indianapolis, IN 46202, USA
Cancers 2018, 10(7), 227; https://doi.org/10.3390/cancers10070227
Received: 4 June 2018 / Revised: 3 July 2018 / Accepted: 5 July 2018 / Published: 9 July 2018
(This article belongs to the Special Issue The Tumor Microenvironment of High Grade Serous Ovarian Cancer)
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Abstract

As one of the important cancer hallmarks, metabolism reprogramming, including lipid metabolism alterations, occurs in tumor cells and the tumor microenvironment (TME). It plays an important role in tumorigenesis, progression, and metastasis. Lipids, and several lysophospholipids in particular, are elevated in the blood, ascites, and/or epithelial ovarian cancer (EOC) tissues, making them not only useful biomarkers, but also potential therapeutic targets. While the roles and signaling of these lipids in tumor cells are extensively studied, there is a significant gap in our understanding of their regulations and functions in the context of the microenvironment. This review focuses on the recent study development in several oncolipids, including lysophosphatidic acid and sphingosine-1-phosphate, with emphasis on TME in ovarian cancer. View Full-Text
Keywords: lipids; lysophospholipids (LPLs); lysophosphatidic acid (LPA); sphingosine-1-phosphate; tumor microenvironment (TME); epithelial ovarian cancer (EOC) lipids; lysophospholipids (LPLs); lysophosphatidic acid (LPA); sphingosine-1-phosphate; tumor microenvironment (TME); epithelial ovarian cancer (EOC)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Xu, Y. Lysophospholipid Signaling in the Epithelial Ovarian Cancer Tumor Microenvironment. Cancers 2018, 10, 227.

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