Next Article in Journal
Comprehensive Analysis of Germline Variants in Mexican Patients with Hereditary Breast and Ovarian Cancer Susceptibility
Next Article in Special Issue
Sensitization of Cancer Cells to Radiation and Topoisomerase I Inhibitor Camptothecin Using Inhibitors of PARP and Other Signaling Molecules
Previous Article in Journal
The Cooperative Relationship between STAT5 and Reactive Oxygen Species in Leukemia: Mechanism and Therapeutic Potential
Previous Article in Special Issue
NGAL is Downregulated in Oral Squamous Cell Carcinoma and Leads to Increased Survival, Proliferation, Migration and Chemoresistance
Article Menu
Issue 10 (October) cover image

Export Article

Open AccessReview

Ionophores: Potential Use as Anticancer Drugs and Chemosensitizers

1
Department of Pharmaceutical Sciences, School of Pharmacy, Hampton University, Hampton, VA 23668, USA
2
Great Plains Health, North Platte, NE 69101, USA
*
Author to whom correspondence should be addressed.
Cancers 2018, 10(10), 360; https://doi.org/10.3390/cancers10100360
Received: 23 August 2018 / Revised: 13 September 2018 / Accepted: 21 September 2018 / Published: 27 September 2018
(This article belongs to the Special Issue Sensitization Strategies in Cancer Treatment)
  |  
PDF [734 KB, uploaded 27 September 2018]
  |  

Abstract

Ion homeostasis is extremely important for the survival of both normal as well as neoplastic cells. The altered ion homeostasis found in cancer cells prompted the investigation of several ionophores as potential anticancer agents. Few ionophores, such as Salinomycin, Nigericin and Obatoclax, have demonstrated potent anticancer activities against cancer stem-like cells that are considered highly resistant to chemotherapy and responsible for tumor relapse. The preclinical success of these compounds in in vitro and in vivo models have not been translated into clinical trials. At present, phase I/II clinical trials demonstrated limited benefit of Obatoclax alone or in combination with other anticancer drugs. However, future development in targeted drug delivery may be useful to improve the efficacy of these compounds. Alternatively, these compounds may be used as leading molecules for the development of less toxic derivatives. View Full-Text
Keywords: ionophores; chemosensitization; obatoclax; nigericin; salinomycin; combination chemotherapy; stem cells ionophores; chemosensitization; obatoclax; nigericin; salinomycin; combination chemotherapy; stem cells
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Kaushik, V.; Yakisich, J.S.; Kumar, A.; Azad, N.; Iyer, A.K.V. Ionophores: Potential Use as Anticancer Drugs and Chemosensitizers. Cancers 2018, 10, 360.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top