Template Stripping Method-Based Au Nanoarray for Surface-Enhanced Raman Scattering Detection of Antiepileptic Drug
1
Graduate School of Engineering, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai-shi, Osaka 599-8531, Japan
2
JST PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan
3
Department of Electronics & Computer Engineering, Hiroshima Institute of Technology, 2-1-1 Miyake, Saeki-ku, Hiroshima 731-5193, Japan
*
Author to whom correspondence should be addressed.
Micromachines 2020, 11(10), 936; https://doi.org/10.3390/mi11100936
Received: 31 August 2020
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Revised: 12 October 2020
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Accepted: 13 October 2020
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Published: 14 October 2020
(This article belongs to the Special Issue Micro and Nano Devices for Cell Analysis)
Surface-enhanced Raman scattering (SERS) is a potential candidate for highly sensitive detection of target molecules. A SERS active substrate with a noble metal nanostructure is required for this. However, a SERS active substrate requires complicated fabrication procedures. This in turn makes it difficult to fabricate highly sensitive SERS active substrates with high reproducibility. To overcome this difficulty, a plasmonic crystal (PC) with periodic noble metal nanostructures was fabricated via the template-stripping method using a polymer-based template. Using SERS active substrates, SERS was successfully achieved using the PC by detecting low concentrations of phenobarbital which is an antiepileptic drug using a commercially available portable Raman module. The PC can be fabricated by demolding the deposited gold layer from a polymer-based template. This method is rapid, economic, and has high reproducibility. SERS can be achieved easily using this PC for a wide variety of applications such as medical, pharmaceutical, and environmental protection.
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Keywords:
plasmonic crystal; template stripping method; surface-enhanced Raman scattering; phenobarbital; antiepileptic drug
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MDPI and ACS Style
Endo, T.; Yamada, H.; Yamada, K. Template Stripping Method-Based Au Nanoarray for Surface-Enhanced Raman Scattering Detection of Antiepileptic Drug. Micromachines 2020, 11, 936. https://doi.org/10.3390/mi11100936
AMA Style
Endo T, Yamada H, Yamada K. Template Stripping Method-Based Au Nanoarray for Surface-Enhanced Raman Scattering Detection of Antiepileptic Drug. Micromachines. 2020; 11(10):936. https://doi.org/10.3390/mi11100936
Chicago/Turabian StyleEndo, Tatsuro, Hirotaka Yamada, and Kenji Yamada. 2020. "Template Stripping Method-Based Au Nanoarray for Surface-Enhanced Raman Scattering Detection of Antiepileptic Drug" Micromachines 11, no. 10: 936. https://doi.org/10.3390/mi11100936
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