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Controlled Focused Ion Beam Milling of Composite Solid State Nanopore Arrays for Molecule Sensing

Microsystems Lab, Inst. of Technical Physics and Materials Science, Centre for Energy Research, Budapest H-1121, Hungary
Micromachines 2019, 10(11), 774; https://doi.org/10.3390/mi10110774
Received: 5 October 2019 / Revised: 7 November 2019 / Accepted: 11 November 2019 / Published: 13 November 2019
(This article belongs to the Special Issue Nanomaterials-Based Biosensors)
Various nanoscale fabrication techniques are elaborated to form artificial nanoporous/nanochannel membranes to be applied for biosensing: one of the most prevalent is the micro-electromechanical systems (MEMS) compatible focused ion beam (FIB) milling. This technique can be easily adopted in micro- and nanomachining process sequences to develop composite multi-pore structures, although its precision and reproducibility are key points in the case of these thick multi-layered membranes. This work is to demonstrate a comprehensive characterisation of FIB milling to improve the reliability of the fabrication of solid state nanopore arrays with precisely predetermined pore geometries for a targeted molecule type to be recognised. The statistical geometric features of the fabricated nanopores were recorded as the function of the process parameters, and the resulting geometries were analysed in detail by high resolution scanning electron microscope (SEM), transmission electron microscope (TEM) and ion scanning microscopy. Continuous function of the pore diameter evolution rate was derived from the experimental results in the case of different material structures, and compared to former dissentient estimations. The additional metal layer was deposited onto the backside of the membrane and grounded during the ion milling to prevent the electrical charging of dielectric layers. The study proved that the conformity of the pore geometry and the reliability of their fabrication could be improved significantly. The applicability of the developed nanopore arrays for molecule detection was also considered by characterising the pore diameter dependent sensitivity of the membrane impedance modulation based measurement method. View Full-Text
Keywords: nanofluidics; nanofabrication; focused ion beam milling; composite/multi-layer solid state nanopore array; molecule detection nanofluidics; nanofabrication; focused ion beam milling; composite/multi-layer solid state nanopore array; molecule detection
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Fürjes, P. Controlled Focused Ion Beam Milling of Composite Solid State Nanopore Arrays for Molecule Sensing. Micromachines 2019, 10, 774.

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