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Open AccessArticle

Comprehensive Evaluation of the Efficiency of Yeast Cell Wall Extract to Adsorb Ochratoxin A and Mitigate Accumulation of the Toxin in Broiler Chickens

1
Alimetrics Research Ltd., 02920 Espoo, Finland
2
Alltech Inc., 3031 Catnip Hill Road, Nicholasville, KY 40356, USA
3
Alltech SARL, Rue Charles Amand, 14500 Vire, France
*
Author to whom correspondence should be addressed.
Toxins 2020, 12(1), 37; https://doi.org/10.3390/toxins12010037
Received: 28 October 2019 / Revised: 13 December 2019 / Accepted: 31 December 2019 / Published: 7 January 2020
(This article belongs to the Special Issue Mycotoxin Exposure and Related Diseases)
Ochratoxin A (OTA) is a common mycotoxin contaminant in animal feed. When absorbed from the gastrointestinal tract, OTA has a propensity for pathological effects on animal health and deposition in animal tissues. In this study, the potential of yeast cell wall extracts (YCWE) to adsorb OTA was evaluated using an in vitro method in which consecutive animal digestion events were simulated. Low pH markedly increased OTA binding to YCWE, which was reversed with a pH increased to 6.5. Overall, in vitro analysis revealed that 30% of OTA was adsorbed to YCWE. Additional computational molecular modelling revealed that change in pH alters the OTA charge and modulates the interaction with the YCWE β-d-glucans. The effectiveness of YCWE was tested in a 14-day broiler chicken trial. Birds were subjected to five dietary treatments; with and without OTA, and OTA combined with YCWE at three dosages. At the end of the trial, liver OTA deposition was evaluated. Data showed a decrease of up to 30% in OTA deposits in the liver of broilers fed both OTA and YCWE. In the case of OTA, a tight correlation between the mitigation efficacy of YCWE between in vitro and in vivo model could be observed. View Full-Text
Keywords: ochratoxin A; mitigation; mycotoxin binding; yeast cell wall extracts ochratoxin A; mitigation; mycotoxin binding; yeast cell wall extracts
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Vartiainen, S.; Yiannikouris, A.; Apajalahti, J.; Moran, C.A. Comprehensive Evaluation of the Efficiency of Yeast Cell Wall Extract to Adsorb Ochratoxin A and Mitigate Accumulation of the Toxin in Broiler Chickens. Toxins 2020, 12, 37.

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