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Toxins 2019, 11(1), 46; https://doi.org/10.3390/toxins11010046

Effects of Ultrasound-Guided Administration of Botulinum Toxin (IncobotulinumtoxinA) in Patients with Lateral Epicondylitis

1
Physical Medicine and Rehabilitation, Hospital Universitario Virgen del Rocío, 41013 Seville, Spain
2
Pharmacology, Pediatrics and Radiology Department, University of Seville, 41004 Seville, Spain
3
Motion Analysis Laboratory, Spaulding Rehabilitation Hospital, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA 02129, USA
*
Author to whom correspondence should be addressed.
Received: 3 October 2018 / Revised: 7 January 2019 / Accepted: 11 January 2019 / Published: 15 January 2019
(This article belongs to the Special Issue Botulinum Toxin Treatment of Movement Disorders)
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Abstract

How effective and safe are incobotulinumtoxinA injections in adult patients with lateral epicondylitis refractory to other treatments? In this experimental study, ultrasound-guided incobotulinumtoxinA 10–30 U/muscle was injected into extensor carpi ulnaris, extensor digiti minimi, extensor digitorum longus and extensor carpi radialis brevis muscles. Pain (visual analogue scale [VAS], 0 to 10 [no pain to severe pain]) and upper-limb functionality (QuickDASH scale, 0 to 100 [best to worst]), assessed at baseline, 1, 3 and 6 months post-treatment, were analysed using repeated-measures analysis of variance (ANOVA) and Tukey post-hoc tests. Secondary analyses stratifying patient population by sex and baseline VAS were performed. Adverse events were reported. Twenty-four patients (mean [standard deviation] age 46.8 years) were included. Compared with baseline, mean VAS and QuickDASH scores improved at all follow-ups (p < 0.001 and p = 0.001, respectively; repeated-measures ANOVA). Secondary analyses revealed significant differences between baseline and all follow-ups in the group with baseline VAS ≥ 6 and in males and females (all p < 0.05, Tukey post-hoc test). No adverse events, except for the expected third finger weakness, were reported. In conclusion, ultrasound-guided incobotulinumtoxinA injections may be an effective treatment for lateral epicondylitis in the appropriate patient population. View Full-Text
Keywords: lateral epicondylitis; tennis elbow; botulinum toxin A; incobotulinumtoxinA; pain; rehabilitation lateral epicondylitis; tennis elbow; botulinum toxin A; incobotulinumtoxinA; pain; rehabilitation
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Galván Ruiz, A.; Vergara Díaz, G.; Rendón Fernández, B.; Echevarría Ruiz De Vargas, C. Effects of Ultrasound-Guided Administration of Botulinum Toxin (IncobotulinumtoxinA) in Patients with Lateral Epicondylitis. Toxins 2019, 11, 46.

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