Association and Interaction Effect of AGTR1 and AGTR2 Gene Polymorphisms with Dietary Pattern on Metabolic Risk Factors of Cardiovascular Disease in Malaysian Adults
1
School of Biosciences, Taylor’s University, 47500 Subang Jaya, Malaysia
2
Graduate School of Human Health Science, University of Nagasaki, Nagayo-cho, Nagasaki 851-2195, Japan
3
Faculty of Applied Sciences, UCSI University, Taman Connaught, 56000 Kuala Lumpur, Malaysia
*
Author to whom correspondence should be addressed.
Nutrients 2017, 9(8), 853; https://doi.org/10.3390/nu9080853
Received: 26 May 2017 / Revised: 25 July 2017 / Accepted: 7 August 2017 / Published: 9 August 2017
(This article belongs to the Special Issue Selected Papers from APNNO Biennial Conference 2016)
Gene-diet interaction using a multifactorial approach is preferred to study the multiple risk factors of cardiovascular disease (CVD). This study examined the association and gene-diet interaction effects of the angiotensin II type 1 receptor (AGTR1) gene (rs5186), and type 2 receptor (AGTR2) gene (rs1403543) polymorphisms on metabolic risk factors of CVD in Malaysian adults. CVD parameters (BMI, blood pressure, glycated hemoglobin, total cholesterol (TC), triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), and TC/HDL-C ratio), and constructed dietary patterns “vegetables, fruits, and soy diet” (VFSD), and “rice, egg, and fish diet” (REFD) were obtained from previous studies. Genotyping analysis was performed by real-time PCR using Taqman probes. The subjects were 507 adults (151 Malays; 179 Chinese; and 177 Indians). Significant genetic associations were obtained on blood lipids for rs5186 in Malays and Chinese, and rs1403543 in Chinese females. The significant gene-diet interaction effects after adjusting for potential confounders were: rs5186 × VFSD on blood pressure in Malays (p = 0.016), and in Chinese on blood lipids for rs5186 × REFD (p = 0.009–0.023), and rs1403543 × VFSD in female subjects (p = 0.001–0.011). Malays and Chinese showed higher risk for blood pressure and/or lipids involving rs5186 and rs1403543 SNPs together with gene-diet interactions, but not Indians.
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Keywords:
gene-diet interaction; AGTR1; AGTR2; rs5186; rs1403543; blood lipids; blood pressure; Malaysian adults
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MDPI and ACS Style
Yap, R.W.K.; Shidoji, Y.; Yap, W.S.; Masaki, M. Association and Interaction Effect of AGTR1 and AGTR2 Gene Polymorphisms with Dietary Pattern on Metabolic Risk Factors of Cardiovascular Disease in Malaysian Adults. Nutrients 2017, 9, 853.
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