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PREVIEW: Prevention of Diabetes through Lifestyle Intervention and Population Studies in Europe and around the World. Design, Methods, and Baseline Participant Description of an Adult Cohort Enrolled into a Three-Year Randomised Clinical Trial

Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose Diet

Center of Neuroscience and Cell Biology (CNC) and CNC.IBILI Research Consortium, University of Coimbra, 3004-504 Coimbra, Portugal
Laboratory of Pharmacology and Experimental Therapeutics, Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal
Service of Anatomical Pathology, Coimbra University Hospital Centre (CHUC), 3000-075 Coimbra, Portugal
The Portuguese Diabetes Association (APDP), 1250-203 Lisbon, Portugal
Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
Arkansas Children’s Hospital Research Institute, Little Rock, AR 72202, USA
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2017, 9(6), 638;
Received: 2 April 2017 / Revised: 8 June 2017 / Accepted: 14 June 2017 / Published: 21 June 2017
(This article belongs to the Special Issue Nutrition and Diet Factors in Type 2 Diabetes)
Glucotoxicity and lipotoxicity are key features of type 2 diabetes mellitus, but their molecular nature during the early stages of the disease remains to be elucidated. We aimed to characterize glucose and lipid metabolism in insulin-target organs (liver, skeletal muscle, and white adipose tissue) in a rat model treated with a high-sucrose (HSu) diet. Two groups of 16-week-old male Wistar rats underwent a 9-week protocol: HSu diet (n = 10)—received 35% of sucrose in drinking water; Control (n = 12)—received vehicle (water). Body weight, food, and beverage consumption were monitored and glucose, insulin, and lipid profiles were measured. Serum and liver triglyceride concentrations, as well as the expression of genes and proteins involved in lipid biosynthesis were assessed. The insulin-stimulated glucose uptake and isoproterenol-stimulated lipolysis were also measured in freshly isolated adipocytes. Even in the absence of obesity, this rat model already presented the main features of prediabetes, with fasting normoglycemia but reduced glucose tolerance, postprandial hyperglycemia, compensatory hyperinsulinemia, as well as decreased insulin sensitivity (resistance) and hypertriglyceridemia. In addition, impaired hepatic function, including altered gluconeogenic and lipogenic pathways, as well as increased expression of acetyl-coenzyme A carboxylase 1 and fatty acid synthase in the liver, were observed, suggesting that liver glucose and lipid dysmetabolism may play a major role at this stage of the disease. View Full-Text
Keywords: high-sucrose diet; prediabetes; glucose; lipid; metabolism; hypertriglyceridemia high-sucrose diet; prediabetes; glucose; lipid; metabolism; hypertriglyceridemia
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MDPI and ACS Style

Burgeiro, A.; Cerqueira, M.G.; Varela-Rodríguez, B.M.; Nunes, S.; Neto, P.; Pereira, F.C.; Reis, F.; Carvalho, E. Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose Diet. Nutrients 2017, 9, 638.

AMA Style

Burgeiro A, Cerqueira MG, Varela-Rodríguez BM, Nunes S, Neto P, Pereira FC, Reis F, Carvalho E. Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose Diet. Nutrients. 2017; 9(6):638.

Chicago/Turabian Style

Burgeiro, Ana, Manuela G. Cerqueira, Bárbara M. Varela-Rodríguez, Sara Nunes, Paula Neto, Frederico C. Pereira, Flávio Reis, and Eugénia Carvalho. 2017. "Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose Diet" Nutrients 9, no. 6: 638.

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