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Nutrients
Volume 9
Issue 6
10.3390/nu9060632
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Article

PREVIEW: Prevention of Diabetes through Lifestyle Intervention and Population Studies in Europe and around the World. Design, Methods, and Baseline Participant Description of an Adult Cohort Enrolled into a Three-Year Randomised Clinical Trial

by
Mikael Fogelholm
1,*,
Thomas Meinert Larsen
2,
Margriet Westerterp-Plantenga
3,
Ian Macdonald
4,
J. Alfredo Martinez
5,6,
Nadka Boyadjieva
7,
Sally Poppitt
8,
Wolfgang Schlicht
9,
Gareth Stratton
10,
Jouko Sundvall
11,
Tony Lam
12,
Elli Jalo
1,
Pia Christensen
2,
Mathijs Drummen
3,
Elizabeth Simpson
4,
Santiago Navas-Carretero
5,6,
Teodora Handjieva-Darlenska
7,
Roslyn Muirhead
13,
Marta P. Silvestre
8,
Daniela Kahlert
14,
Laura Pastor-Sanz
2,
Jennie Brand-Miller
13 and
Anne Raben
2add Show full author list remove Hide full author list
1
Department of Food and Environmental Sciences, University of Helsinki, 00014 Helsinki, Finland
2
Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Rolighedsvej 30, Frederiksberg C, DK-1958 Copenhagen, Denmark
3
Department of Human Biology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
4
School of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham NG7 2UH, UK
5
Center for Nutrition Research, University of Navarra, 31008 Pamplona, Spain
6
CIBERobn, Instituto de Salud Carlos III, 28029 Madrid, Spain
7
Department of pharmacology and toxicology, Medical University of Sofia, 1431 Sofia, Bulgaria
8
Human Nutrition Unit, School of Biological Sciences, University of Auckland, Auckland 1024, New Zealand
9
Department of Exercise and Health Sciences, University of Stuttgart, 70569 Stuttgart, Germany
10
School of Sport and Exercise Sciences, A.STEM Research Centre, Swansea University, Swansea SA1 8EN, UK
11
National Institute for Health and Welfare THL, 00300 Helsinki, Finland
12
NetUnion sarl, Ave des Figuires 20, 1007 Lausanne, Switzerland
13
Charles Perkins Centre, University of Sydney, Sydney 2006, Australia
14
Department of Health Science, University of Education Schwäbisch Gmünd, 73525 Gmünd, Germany
 
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*
Author to whom correspondence should be addressed.
Nutrients 2017, 9(6), 632; https://doi.org/10.3390/nu9060632
Received: 14 May 2017 / Revised: 4 June 2017 / Accepted: 16 June 2017 / Published: 20 June 2017
(This article belongs to the Special Issue Nutrition and Diet Factors in Type 2 Diabetes)
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Abstract

Type-2 diabetes (T2D) is one of the fastest growing chronic diseases worldwide. The PREVIEW project has been initiated to find the most effective lifestyle (diet and physical activity) for the prevention of T2D, in overweight and obese participants with increased risk for T2D. The study is a three-year multi-centre, 2 × 2 factorial, randomised controlled trial. The impact of a high-protein, low-glycaemic index (GI) vs. moderate protein, moderate-GI diet in combination with moderate or high-intensity physical activity on the incidence of T2D and the related clinical end-points are investigated. The intervention started with a two-month weight reduction using a low-calorie diet, followed by a randomised 34-month weight maintenance phase comprising four treatment arms. Eight intervention centres are participating (Denmark, Finland, United Kingdom, The Netherlands, Spain, Bulgaria, Australia, and New Zealand). Data from blood specimens, urine, faeces, questionnaires, diaries, body composition assessments, and accelerometers are collected at months 0, 2, 6, 12, 18, 24, and 36. In total, 2326 adults were recruited. The mean age was 51.6 (SD 11.6) years, 67% were women. PREVIEW is, to date, the largest multinational trial to address the prevention of T2D in pre-diabetic adults through diet and exercise intervention. Participants will complete the final intervention in March, 2018. View Full-Text
Keywords: diet; protein; carbohydrate; glycaemic index; physical activity; obesity diet; protein; carbohydrate; glycaemic index; physical activity; obesity
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MDPI and ACS Style

Fogelholm, M.; Larsen, T.M.; Westerterp-Plantenga, M.; Macdonald, I.; Martinez, J.A.; Boyadjieva, N.; Poppitt, S.; Schlicht, W.; Stratton, G.; Sundvall, J.; Lam, T.; Jalo, E.; Christensen, P.; Drummen, M.; Simpson, E.; Navas-Carretero, S.; Handjieva-Darlenska, T.; Muirhead, R.; Silvestre, M.P.; Kahlert, D.; Pastor-Sanz, L.; Brand-Miller, J.; Raben, A. PREVIEW: Prevention of Diabetes through Lifestyle Intervention and Population Studies in Europe and around the World. Design, Methods, and Baseline Participant Description of an Adult Cohort Enrolled into a Three-Year Randomised Clinical Trial. Nutrients 2017, 9, 632. https://doi.org/10.3390/nu9060632

AMA Style

Fogelholm M, Larsen TM, Westerterp-Plantenga M, Macdonald I, Martinez JA, Boyadjieva N, Poppitt S, Schlicht W, Stratton G, Sundvall J, Lam T, Jalo E, Christensen P, Drummen M, Simpson E, Navas-Carretero S, Handjieva-Darlenska T, Muirhead R, Silvestre MP, Kahlert D, Pastor-Sanz L, Brand-Miller J, Raben A. PREVIEW: Prevention of Diabetes through Lifestyle Intervention and Population Studies in Europe and around the World. Design, Methods, and Baseline Participant Description of an Adult Cohort Enrolled into a Three-Year Randomised Clinical Trial. Nutrients. 2017; 9(6):632. https://doi.org/10.3390/nu9060632

Chicago/Turabian Style

Fogelholm, Mikael, Thomas M. Larsen, Margriet Westerterp-Plantenga, Ian Macdonald, J. A. Martinez, Nadka Boyadjieva, Sally Poppitt, Wolfgang Schlicht, Gareth Stratton, Jouko Sundvall, Tony Lam, Elli Jalo, Pia Christensen, Mathijs Drummen, Elizabeth Simpson, Santiago Navas-Carretero, Teodora Handjieva-Darlenska, Roslyn Muirhead, Marta P. Silvestre, Daniela Kahlert, Laura Pastor-Sanz, Jennie Brand-Miller, and Anne Raben. 2017. "PREVIEW: Prevention of Diabetes through Lifestyle Intervention and Population Studies in Europe and around the World. Design, Methods, and Baseline Participant Description of an Adult Cohort Enrolled into a Three-Year Randomised Clinical Trial" Nutrients 9, no. 6: 632. https://doi.org/10.3390/nu9060632

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