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Nutrients 2017, 9(6), 632;

PREVIEW: Prevention of Diabetes through Lifestyle Intervention and Population Studies in Europe and around the World. Design, Methods, and Baseline Participant Description of an Adult Cohort Enrolled into a Three-Year Randomised Clinical Trial

Department of Food and Environmental Sciences, University of Helsinki, 00014 Helsinki, Finland
Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Rolighedsvej 30, Frederiksberg C, DK-1958 Copenhagen, Denmark
Department of Human Biology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
School of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham NG7 2UH, UK
Center for Nutrition Research, University of Navarra, 31008 Pamplona, Spain
CIBERobn, Instituto de Salud Carlos III, 28029 Madrid, Spain
Department of pharmacology and toxicology, Medical University of Sofia, 1431 Sofia, Bulgaria
Human Nutrition Unit, School of Biological Sciences, University of Auckland, Auckland 1024, New Zealand
Department of Exercise and Health Sciences, University of Stuttgart, 70569 Stuttgart, Germany
School of Sport and Exercise Sciences, A.STEM Research Centre, Swansea University, Swansea SA1 8EN, UK
National Institute for Health and Welfare THL, 00300 Helsinki, Finland
NetUnion sarl, Ave des Figuires 20, 1007 Lausanne, Switzerland
Charles Perkins Centre, University of Sydney, Sydney 2006, Australia
Department of Health Science, University of Education Schwäbisch Gmünd, 73525 Gmünd, Germany
Author to whom correspondence should be addressed.
Received: 14 May 2017 / Revised: 4 June 2017 / Accepted: 16 June 2017 / Published: 20 June 2017
(This article belongs to the Special Issue Nutrition and Diet Factors in Type 2 Diabetes)
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Type-2 diabetes (T2D) is one of the fastest growing chronic diseases worldwide. The PREVIEW project has been initiated to find the most effective lifestyle (diet and physical activity) for the prevention of T2D, in overweight and obese participants with increased risk for T2D. The study is a three-year multi-centre, 2 × 2 factorial, randomised controlled trial. The impact of a high-protein, low-glycaemic index (GI) vs. moderate protein, moderate-GI diet in combination with moderate or high-intensity physical activity on the incidence of T2D and the related clinical end-points are investigated. The intervention started with a two-month weight reduction using a low-calorie diet, followed by a randomised 34-month weight maintenance phase comprising four treatment arms. Eight intervention centres are participating (Denmark, Finland, United Kingdom, The Netherlands, Spain, Bulgaria, Australia, and New Zealand). Data from blood specimens, urine, faeces, questionnaires, diaries, body composition assessments, and accelerometers are collected at months 0, 2, 6, 12, 18, 24, and 36. In total, 2326 adults were recruited. The mean age was 51.6 (SD 11.6) years, 67% were women. PREVIEW is, to date, the largest multinational trial to address the prevention of T2D in pre-diabetic adults through diet and exercise intervention. Participants will complete the final intervention in March, 2018. View Full-Text
Keywords: diet; protein; carbohydrate; glycaemic index; physical activity; obesity diet; protein; carbohydrate; glycaemic index; physical activity; obesity

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Fogelholm, M.; Larsen, T.M.; Westerterp-Plantenga, M.; Macdonald, I.; Martinez, J.A.; Boyadjieva, N.; Poppitt, S.; Schlicht, W.; Stratton, G.; Sundvall, J.; Lam, T.; Jalo, E.; Christensen, P.; Drummen, M.; Simpson, E.; Navas-Carretero, S.; Handjieva-Darlenska, T.; Muirhead, R.; Silvestre, M.P.; Kahlert, D.; Pastor-Sanz, L.; Brand-Miller, J.; Raben, A. PREVIEW: Prevention of Diabetes through Lifestyle Intervention and Population Studies in Europe and around the World. Design, Methods, and Baseline Participant Description of an Adult Cohort Enrolled into a Three-Year Randomised Clinical Trial. Nutrients 2017, 9, 632.

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