Next Article in Journal
A Multi-Center Assessment of Nutrient Levels and Foods Provided by Hospital Patient Menus
Next Article in Special Issue
The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility
Previous Article in Journal
Inverse Correlation between Vitamin D and C-Reactive Protein in Newborns
Previous Article in Special Issue
Antibacterial Effects of Cinnamon: From Farm to Food, Cosmetic and Pharmaceutical Industries
Open AccessReview

Cell Systems to Investigate the Impact of Polyphenols on Cardiovascular Health

1
Laboratory of Food Chemistry and Human Nutrition, Department of Food Safety and Food Quality, Faculty of Bioscience Engineering, Ghent University, Coupure Links, Ghent 653 B-9000, Belgium
2
Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak 34469, Istanbul, Turkey
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2015, 7(11), 9229-9255; https://doi.org/10.3390/nu7115462
Received: 21 September 2015 / Revised: 21 October 2015 / Accepted: 28 October 2015 / Published: 11 November 2015
Polyphenols are a diverse group of micronutrients from plant origin that may serve as antioxidants and that contribute to human health in general. More specifically, many research groups have investigated their protective effect against cardiovascular diseases in several animal studies and human trials. Yet, because of the excessive processing of the polyphenol structure by human cells and the residing intestinal microbial community, which results in a large variability between the test subjects, the exact mechanisms of their protective effects are still under investigation. To this end, simplified cell culture systems have been used to decrease the inter-individual variability in mechanistic studies. In this review, we will discuss the different cell culture models that have been used so far for polyphenol research in the context of cardiovascular diseases. We will also review the current trends in cell culture research, including co-culture methodologies. Finally, we will discuss the potential of these advanced models to screen for cardiovascular effects of the large pool of bioactive polyphenols present in foods and their metabolites. View Full-Text
Keywords: co-culture; cytokine; endothelium; intestine; liver co-culture; cytokine; endothelium; intestine; liver
Show Figures

Figure 1

MDPI and ACS Style

Grootaert, C.; Kamiloglu, S.; Capanoglu, E.; Van Camp, J. Cell Systems to Investigate the Impact of Polyphenols on Cardiovascular Health. Nutrients 2015, 7, 9229-9255.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop