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The Role of Mechanistic Target of Rapamycin (mTOR) Complexes Signaling in the Immune Responses

Department of Health Promotion, Social and Behavioral Health Sciences, College of Public Health, University of Nebraska Medical Center, 984365 Nebraska Medical Center, Omaha, NE 68198, USA
Nutrients 2013, 5(6), 2231-2257; https://doi.org/10.3390/nu5062231
Received: 15 April 2013 / Revised: 5 June 2013 / Accepted: 5 June 2013 / Published: 19 June 2013
(This article belongs to the Special Issue Nutrients and Immune Function)
The mechanistic Target of Rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase which is a member of the PI3K related kinase (PIKK) family. mTOR emerged as a central node in cellular metabolism, cell growth, and differentiation, as well as cancer metabolism. mTOR senses the nutrients, energy, insulin, growth factors, and environmental cues and transmits signals to downstream targets to effectuate the cellular and metabolic response. Recently, mTOR was also implicated in the regulation of both the innate and adaptive immune responses. This paper will summarize the current knowledge of mTOR, as related to the immune microenvironment and immune responses. View Full-Text
Keywords: mTOR; innate immunity; adaptive immunity; regulatory T cells; T helper; B cells; rapamycin; immunosuppression; mTORC1; mTORC2 mTOR; innate immunity; adaptive immunity; regulatory T cells; T helper; B cells; rapamycin; immunosuppression; mTORC1; mTORC2
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Soliman, G.A. The Role of Mechanistic Target of Rapamycin (mTOR) Complexes Signaling in the Immune Responses. Nutrients 2013, 5, 2231-2257.

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