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Modulation of Immune Function by Polyphenols: Possible Contribution of Epigenetic Factors

Center of Molecular Biology and Pharmacogenetics, Scientific and Technological Bioresource Nucleus, Universidad de La Frontera (BIOREN-UFRO), Temuco 4811230, Chile
Department of Clinical and Toxicology Analysis, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo 05508-900, Brazil
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2013, 5(7), 2314-2332;
Received: 4 April 2013 / Revised: 15 May 2013 / Accepted: 26 May 2013 / Published: 28 June 2013
(This article belongs to the Special Issue Nutrients and Immune Function)
PDF [550 KB, uploaded 28 June 2013]


Several biological activities have been described for polyphenolic compounds, including a modulator effect on the immune system. The effects of these biologically active compounds on the immune system are associated to processes as differentiation and activation of immune cells. Among the mechanisms associated to immune regulation are epigenetic modifications as DNA methylation of regulatory sequences, histone modifications and posttranscriptional repression by microRNAs that influences the gene expression of key players involved in the immune response. Considering that polyphenols are able to regulate the immune function and has been also demonstrated an effect on epigenetic mechanisms, it is possible to hypothesize that there exists a mediator role of epigenetic mechanisms in the modulation of the immune response by polyphenols. View Full-Text
Keywords: polyphenols; immune system; epigenetic polyphenols; immune system; epigenetic

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Cuevas, A.; Saavedra, N.; Salazar, L.A.; Abdalla, D.S.P. Modulation of Immune Function by Polyphenols: Possible Contribution of Epigenetic Factors. Nutrients 2013, 5, 2314-2332.

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