Post-Diagnostic Lifestyle Adaptations in Fibromyalgia: A Network and Cluster Analysis of Real-World Behavioral Patterns
Abstract
1. Introduction
2. Materials and Methods
2.1. Ethics
2.2. Study Design and Participants
2.3. Assessment of Physical Activity
2.4. Statistical Analysis
3. Results
3.1. Baseline Characteristics and Physical Activity
3.2. Direction and Frequency of Post-Diagnostic Dietary Modifications
3.3. Network Structure of Dietary and Physical Activity Adaptations
3.4. Cluster Analysis of Dietary Adaptation Patterns
3.5. Association Between Adaptation Patterns and Symptom Severity
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- Filipovic, T.; Filipović, A.; Nikolic, D.; Gimigliano, F.; Stevanov, J.; Hrkovic, M.; Bosanac, I. Fibromyalgia: Understanding, Diagnosis and Modern Approaches to Treatment. J. Clin. Med. 2025, 14, 955. [Google Scholar] [CrossRef] [PubMed] [PubMed Central]
- Paroli, M.; Gioia, C.; Accapezzato, D.; Caccavale, R. Inflammation, Autoimmunity, and Infection in Fibromyalgia: A Narrative Review. Int. J. Mol. Sci. 2024, 25, 5922. [Google Scholar] [CrossRef] [PubMed] [PubMed Central]
- Jurado-Priego, L.N.; Cueto-Ureña, C.; Ramírez-Expósito, M.J.; Martínez-Martos, J.M. Fibromyalgia: A Review of the Pathophysiological Mechanisms and Multidisciplinary Treatment Strategies. Biomedicines 2024, 12, 1543. [Google Scholar] [CrossRef] [PubMed] [PubMed Central]
- Nicholas, M.; Vlaeyen, J.W.S.; Rief, W.; Barke, A.; Aziz, Q.; Benoliel, R.; Cohen, M.; Evers, S.; Giamberardino, M.A.; Goebel, A.; et al. The IASP classification of chronic pain for ICD-11: Chronic primary pain. Pain 2019, 160, 28–37. [Google Scholar] [CrossRef] [PubMed]
- Perrot, S. Fibromyalgia: A misconnection in a multiconnected world? Eur. J. Pain 2019, 23, 866–873. [Google Scholar] [CrossRef]
- Dizner-Golab, A.; Lisowska, B.; Kosson, D. Fibromyalgia—Etiology, diagnosis and treatment including perioperative management in patients with fibromyalgia. Reumatologia 2023, 61, 137–148. [Google Scholar] [CrossRef] [PubMed] [PubMed Central]
- Mansfield, K.E.; Sim, J.; Jordan, J.L.; Jordan, K.P. A systematic review and meta-analysis of the prevalence of chronic widespread pain in the general population. Pain 2016, 157, 55–64. [Google Scholar] [CrossRef]
- Häuser, W.; Ablin, J.; Fitzcharles, M.A.; Littlejohn, G.; Luciano, J.V.; Usui, C.; Walitt, B. Fibromyalgia. Nat. Rev. Dis. Primers 2015, 1, 15022. [Google Scholar] [CrossRef] [PubMed]
- Häuser, W.; Brähler, E.; Ablin, J.; Wolfe, F. Modified 2016 American College of Rheumatology Fibromyalgia Criteria, the Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities and Networks-American Pain Society Pain Taxonomy, and the Prevalence of Fibromyalgia. Arthritis Care Res. 2021, 73, 617–625. [Google Scholar] [CrossRef] [PubMed]
- Wolfe, F.; Clauw, D.J.; Fitzcharles, M.A.; Goldenberg, D.L.; Häuser, W.; Katz, R.L.; Mease, P.J.; Russell, A.S.; Russell, I.J.; Walitt, B. 2016 Revisions to the 2010/2011 fibromyalgia diagnostic criteria. Semin. Arthritis Rheum. 2016, 46, 319–329. [Google Scholar] [CrossRef]
- Gyorfi, M.; Rupp, A.; Abd-Elsayed, A. Fibromyalgia Pathophysiology. Biomedicines 2022, 10, 3070. [Google Scholar] [CrossRef]
- Malcangio, M. Role of the immune system in neuropathic pain. Scand. J. Pain 2019, 20, 33–37. [Google Scholar] [CrossRef]
- Cagnie, B.; Coppieters, I.; Denecker, S.; Six, J.; Danneels, L.; Meeus, M. Central sensitization in fibromyalgia? A systematic review on structural and functional brain MRI. Semin. Arthritis Rheum. 2014, 44, 68–75. [Google Scholar] [CrossRef] [PubMed]
- Khoo, T.; Hill, C.L.; Hoon, E.; Whittle, S. Patient Perspectives of Disease Activity, Medications and Substance Use in People with Fibromyalgia. Open Access Rheumatol. 2022, 14, 87–95. [Google Scholar] [CrossRef]
- Rus, A.; Lopez-Sanchez, J.A.; Martinez-Martos, J.M.; Ramirez-Exposito, M.J.; Molina, F.; Correa-Rodriguez, M.; Aguilar-Ferrandiz, M.E. Predictive Ability of Serum Amino Acid Levels to Differentiate Fibromyalgia Patients from Healthy Subjects. Mol. Diagn. Ther. 2024, 28, 113–128. [Google Scholar] [CrossRef] [PubMed]
- Rus, A.; Molina, F.; Del Moral, M.L.; Ramirez-Exposito, M.J.; Martinez-Martos, J.M. Catecholamine and Indolamine Pathway: A Case-Control Study in Fibromyalgia. Biol. Res. Nurs. 2018, 20, 577–586. [Google Scholar] [CrossRef]
- Martinez-Martos, J.M.; Correa-Rodriguez, M.; Rus, A.; Molina, F.; Ramirez-Exposito, M.J.; Aguilar-Ferrandiz, M.E. Altered Serum Oxytocinase and Enkephalin-Degrading Aminopeptidase Activities in Patients with Fibromyalgia. Biol. Res. Nurs. 2019, 21, 431–439. [Google Scholar] [CrossRef]
- Macfarlane, G.J.; Kronisch, C.; Dean, L.E.; Atzeni, F.; Häuser, W.; Fluß, E.; Choy, E.; Kosek, E.; Amris, K.; Branco, J.; et al. EULAR revised recommendations for the management of fibromyalgia. Ann. Rheum. Dis. 2017, 76, 318–328. [Google Scholar] [CrossRef]
- Metyas, C.; Aung, T.T.; Cheung, J.; Joseph, M.; Ballester, A.M.; Metyas, S. Diet and Lifestyle Modifications for Fibromyalgia. Curr. Rheumatol. Rev. 2024, 20, 405–413. [Google Scholar] [CrossRef] [PubMed] [PubMed Central]
- Valim, V.; Natour, J.; Xiao, Y.; Pereira, A.F.; Lopes, B.B.; Pollak, D.F.; Zandonade, E.; Russell, I.J. Effects of physical exercise on serum levels of serotonin and its metabolite in fibromyalgia: A randomized pilot study. Rev. Bras. Reumatol. 2013, 53, 538–541. [Google Scholar] [CrossRef] [PubMed][Green Version]
- McCrae, C.; O’Shea, A.; Boissoneault, J.; Vatthauer, K.; Robinson, M.; Staud, R.; Perlstein, W.; Craggs, J. Fibromyalgia patients have reduced hippocampal volume compared with healthy controls. J. Pain Res. 2015, 8, 47–52. [Google Scholar] [CrossRef]
- Rodrigo, L.; Blanco, I.; Bobes, J.; de Serres, F.J. Effect of one year of a gluten-free diet on the clinical evolution of irritable bowel syndrome plus fibromyalgia in patients with associated lymphocytic enteritis: A case-control study. Arthritis Res. Ther. 2014, 16, 421–431. [Google Scholar] [CrossRef] [PubMed]
- Slim, M.; Calandre, E.P.; Garcia-Leiva, J.M.; Rico-Villademoros, F.; Molina-Barea, R.; Rodriguez-Lopez, C.M.; Morillas-Arques, P. The effects of a gluten-free diet versus a hypocaloric diet among patients with fibromyalgia experiencing gluten sensitivity-like symptoms: A pilot, open-label randomized clinical trial. J. Clin. Gastroenterol. 2017, 51, 500–507. [Google Scholar] [CrossRef]
- Marum, A.P.; Moreira, C.; Saraiva, F.; Tomas-Carus, P.; Sousa-Guerreiro, C. A low fermentable oligo-di-mono saccharides and polyols (FODMAP) diet reduced pain and improved daily life in fibromyalgia patients. Scand. J. Pain 2016, 13, 166–172. [Google Scholar] [CrossRef]
- Azad, K.A.; Alam, M.N.; Haq, S.A.; Nahar, S.; Chowdhury, M.A.; Ali, S.M.; Ullah, A.K. Vegetarian diet in the treatment of fibromyalgia. Bangladesh Med. Res. Counc. Bull. 2000, 26, 41–47. [Google Scholar]
- Martinez-Rodriguez, A.; Rubio-Arias, J.A.; Ramos-Campo, D.J.; Reche-Garcia, C.; Leyva-Vela, B.; Nadal-Nicolas, Y. Psychological and Sleep Effects of Tryptophan and Magnesium-Enriched Mediterranean Diet in Women with Fibromyalgia. Int. J. Environ. Res. Public Health 2020, 17, 2227. [Google Scholar] [CrossRef] [PubMed]
- Catella, S.; Gendreau, R.M.; Kraus, A.C.; Vega, N.; Rosenbluth, M.J.; Soefje, S.; Malhotra, S.; Luciano, J.V.; McCracken, L.M.; Wil-liams, D.A.; et al. Self-guided digital acceptance and commitment therapy for fibromyalgia management: Re-sults of a randomized, active-controlled, phase II pilot clinical trial. J. Behav. Med. 2024, 47, 27–42. [Google Scholar] [CrossRef] [PubMed] [PubMed Central]
- Busch, A.J.; Webber, S.C.; Brachaniec, M.; Bidonde, J.; Bello-Haas, V.D.; Danyliw, A.D.; Overend, T.J.; Richards, R.S.; Sawant, A.; Schachter, C.L. Exercise therapy for fibromyalgia. Curr. Pain Headache Rep. 2011, 15, 358–367. [Google Scholar] [CrossRef]
- Fernandez-Feijoo, F.; Samartin-Veiga, N.; Carrillo-de-la-Peña, M.T. Quality of life in patients with fibromyalgia: Contributions of disease symptoms, lifestyle and multi-medication. Front. Psychol. 2022, 13, 924405. [Google Scholar] [CrossRef] [PubMed] [PubMed Central]
- Carrasco-Querol, N.; Cabricano-Canga, L.; Bueno Hernández, N.; Gonçalves, A.Q.; Caballol Angelats, R.; Pozo Ariza, M.; Martín-Borràs, C.; Montesó-Curto, P.; Castro Blanco, E.; Dalmau Llorca, M.R.; et al. Nutrition and Chronobiology as Key Components of Multidisciplinary Therapeutic Interventions for Fibromyalgia and Associated Chronic Fatigue Syndrome: A Narrative and Critical Review. Nutrients 2024, 16, 182. [Google Scholar] [CrossRef] [PubMed] [PubMed Central]
- Haute Autorité de Santé (HAS). Fibromyalgia in Adults: Diagnostic Management and Treatment Strategy Guideline; HAS: Saint-Denis, France, 2025. [Google Scholar]
- Bull, F.C.; Al-Ansari, S.S.; Biddle, S.; Borodulin, K.; Buman, M.P.; Cardon, G.; Carty, C.; Chaput, J.P.; Chastin, S.; Chou, R.; et al. World Health Organization 2020 guidelines on physical activity and sedentary behaviour. Br. J. Sports Med. 2020, 54, 1451–1462. [Google Scholar] [CrossRef] [PubMed] [PubMed Central]
- Duhn, P.H.; Wæhrens, E.E.; Pedersen, M.B.; Nielsen, S.M.; Locht, H.; Bliddal, H.; Christensen, R.; Amris, K. Effectiveness of patient education as a stand-alone intervention for patients with chronic widespread pain and fibromyalgia: A systematic review and meta-analysis of randomized trials. Scand. J. Rheumatol. 2023, 52, 654–663. [Google Scholar] [CrossRef]
- Estévez-López, F.; Maestre-Cascales, C.; Russell, D.; Álvarez-Gallardo, I.C.; Rodriguez-Ayllon, M.; Hughes, C.M.; Davison, G.W.; Sañudo, B.; McVeigh, J.G. Effectiveness of exercise on fatigue and sleep quality in fibromyalgia: A systematic review and meta-analysis of randomized trials. Arch. Phys. Med. Rehabil. 2021, 102, 752–761. [Google Scholar] [CrossRef] [PubMed]
- Kundakci, B.; Kaur, J.; Goh, S.L.; Hall, M.; Doherty, M.; Zhang, W.; Abhishek, A. Efficacy of nonpharmacological interventions for individual features of fibromyalgia: A systematic review and meta-analysis of randomised controlled trials. Pain 2022, 163, 1432–1445. [Google Scholar] [CrossRef] [PubMed]
- Llàdser, A.N.; Montesó-Curto, P.; López, C.; Rosselló, L.; Lear, S.; Toussaint, L.; Casadó-Martín, L.C. Multidisciplinary rehabilitation treatments for patients with fibromyalgia: A systematic review. Eur. J. Phys. Rehabil. Med. 2022, 58, 76–84. [Google Scholar] [CrossRef]
- Fitzcharles, M.A.; Cohen, S.P.; Clauw, D.J.; Littlejohn, G.; Usui, C.; Häuser, W. Nociplastic pain: Towards an understanding of prevalent pain conditions. Lancet 2021, 397, 2098–2110. [Google Scholar] [CrossRef] [PubMed]
- Lazaridou, A.; Kim, J.; Cahalan, C.M.; Loggia, M.L.; Franceschelli, O.; Berna, C.; Schur, P.; Napadow, V.; Edwards, R.R. Effects of Cognitive-Behavioral Therapy (CBT) on Brain Connectivity Supporting Catastrophizing in Fibromyalgia. Clin. J. Pain 2017, 33, 215–221. [Google Scholar] [CrossRef] [PubMed] [PubMed Central]
- Estévez-López, F.; Segura-Jiménez, V.; Álvarez-Gallardo, I.C.; Borges-Cosic, M.; Pulido-Martos, M.; Carbonell-Baeza, A.; Aparicio, V.A.; Geenen, R.; Delgado-Fernández, M. Adaptation profiles comprising objective and subjective measures in fibromyalgia: The al-Ándalus project. Rheumatology 2017, 56, 2015–2024. [Google Scholar] [CrossRef] [PubMed][Green Version]
- Bernardy, K.; Klose, P.; Busch, A.J.; Choy, E.H.; Häuser, W. Cognitive behavioural therapies for fibromyalgia. Cochrane Database Syst. Rev. 2013, 2013, CD009796. [Google Scholar] [CrossRef] [PubMed] [PubMed Central]
- Bernardy, K.; Klose, P.; Welsch, P.; Häuser, W. Efficacy, acceptability and safety of cognitive behavioural therapies in fibromyalgia syndrome—A systematic review and meta-analysis of randomized controlled trials. Eur. J. Pain 2018, 22, 242–260. [Google Scholar] [CrossRef]
- Gianlorenço, A.C.; Costa, V.; Fabris-Moraes, W.; Menacho, M.; Alves, L.G.; Martinez-Magallanes, D.; Fregni, F. Cluster analysis in fibromyalgia: A systematic review. Rheumatol. Int. 2024, 44, 2389–2402. [Google Scholar] [CrossRef] [PubMed]
- Xiang, X. Chronic Disease Diagnosis as a Teachable Moment for Health Behavior Changes Among Middle-Aged and Older Adults. J. Aging Health 2016, 28, 995–1015. [Google Scholar] [CrossRef] [PubMed]
- Lawson, P.J.; Flocke, S.A. Teachable moments for health behavior change: A concept analysis. Patient Educ. Couns. 2009, 76, 25–30. [Google Scholar] [CrossRef] [PubMed] [PubMed Central]
- Nijs, J.; George, S.Z.; Clauw, D.J.; Fernández-de-Las-Peñas, C.; Kosek, E.; Ickmans, K.; Fernández-Carnero, J.; Polli, A.; Kapreli, E.; Huysmans, E.; et al. Central sensitisation in chronic pain conditions: Latest discoveries and their potential for precision medicine. Lancet Rheumatol. 2021, 3, e383–e392. [Google Scholar] [CrossRef] [PubMed]
- Pietrzyk, B.; Dolibog, P.; Fajferek, T.; Joniec, A.; Mikołajczyk, J.; Kaczara, S.; Kołodziej, E. The impact of common chronic diseases on the severity of clinical symptoms of COVID-19. Ann. Acad. Medicae Silesiensis 2025, 79, 261–268. [Google Scholar] [CrossRef]
- Castaldo, G.; Marino, C.; Atteno, M.; D’Elia, M.; Pagano, I.; Grimaldi, M.; Conte, A.; Molettieri, P.; Santoro, A.; Napolitano, E.; et al. Investigating the Effectiveness of a Carb-Free Oloproteic Diet in Fibromyalgia Treatment. Nutrients 2024, 16, 1620. [Google Scholar] [CrossRef]
- Casini, I.; Ladisa, V.; Clemente, L.; Delussi, M.; Rostanzo, E.; Peparini, S.; Aloisi, A.M.; de Tommaso, M. A Personalized Mediterranean Diet Improves Pain and Quality of Life in Patients with Fibromyalgia. Pain Ther. 2024, 13, 609–662. [Google Scholar] [CrossRef]
- Silva, A.R.; Bernardo, A.; de Mesquita, M.F.; Vaz-Patto, J.; Moreira, P.; Silva, M.L.; Padrão, P. An anti-inflammatory and low fermentable oligo, di, and monosaccharides and polyols diet improved patient reported outcomes in fibromyalgia: A randomized controlled trial. Front. Nutr. 2022, 9, 856216. [Google Scholar] [CrossRef] [PubMed]
- Ciaffi, J.; Lisi, L.; Mari, A.; Mancarella, L.; Brusi, V.; Pignatti, F.; Ricci, S.; Vitali, G.; Stefanelli, N.; Assirelli, E.; et al. Efficacy, safety and tolerability of very low-calorie ketogenic diet in obese women with fibromyalgia: A pilot interventional study. Front. Nutr. 2023, 10, 1219321. [Google Scholar] [CrossRef]
- Maddox, E.K.; Massoni, S.C.; Hoffart, C.M.; Takata, Y. Dietary Effects on Pain Symptoms in Patients with Fibromyalgia Syndrome: Systematic Review and Future Directions. Nutrients 2023, 15, 716. [Google Scholar] [CrossRef]
- Aslan Çİn, N.N.; Açik, M.; Tertemİz, O.F.; Aktan, Ç.; Akçali, D.T.; Çakiroğlu, F.P.; Özçelİk, A.Ö. Effect of prebiotic and probiotic supplementation on reduced pain in patients with fibromyalgia syndrome: A double-blind, placebo-controlled randomized clinical trial. Psychol. Health Med. 2024, 29, 528–541. [Google Scholar] [CrossRef]





| Parameters | |
|---|---|
| Sex (N) | 88 |
| Female (%) | 84 (95.5%) |
| Male (%) | 4 (4.5%) |
| Age (years), mean ± SD | 46.9 ± 11.3 |
| BMI (kg/m2), mean ± SD | 25.6 ± 4.6 |
| Time since diagnosis | N (%) |
| <3 years | 41 (46.6) |
| 3–6 years | 21 (23.9) |
| >6 years | 26 (29.5) |
| WPI, mean ± SD | 16.68 ± 7.04 |
| SSS, mean ± SD | 6.09 ± 1.79 |
| Type of Physical Activity | N | % |
|---|---|---|
| Walking | 67 | 76.1 |
| Yoga | 26 | 29.5 |
| Cycling | 14 | 15.9 |
| Nordic walking | 10 | 11.4 |
| Swimming | 10 | 8.0 |
| Variable 1 | Variable 2 | Spearman’s p | p-Value | Interpretation |
|---|---|---|---|---|
| Vegetables ↑ | Water ↑ | 0.32 | 0.01 | moderate positive |
| Sugar-sweetened beverages (cola) ↓ | Alcohol ↓ | 0.41 | <0.001 | moderate positive |
| Vegetables ↑ | Cola ↓ | 0.28 | 0.02 | weak-to-moderate positive |
| Vegetables ↑ | Alcohol ↓ | 0.36 | 0.01 | weak-to-moderate positive |
| Cluster | Adaptation Pattern | N (%) | Main Behavioral Characteristics | Mean WPI + SSS ± SD |
|---|---|---|---|---|
| 1 | Comprehensive health-oriented pattern | 14 (15.9) | Increased vegetables, fruits, whole grains, and water intake; reduced meat, alcohol, and sugar-sweetened beverage consumption | 23.21 ± 4.12 |
| 2 | Selective dietary modification pattern | 27 (30.7) | Partial increase in plant-based foods and selective reduction in specific dietary products | 22.92 ± 3.87 |
| 3 | Minimal adaptation pattern | 47 (53.4) | Limited or inconsistent dietary and lifestyle modifications | 22.80 ± 4.55 |
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Kosiorz, M.; Muc-Wierzgoń, M.; Walkiewicz, K.W.; Dzięgielewska-Gęsiak, S. Post-Diagnostic Lifestyle Adaptations in Fibromyalgia: A Network and Cluster Analysis of Real-World Behavioral Patterns. Nutrients 2026, 18, 1791. https://doi.org/10.3390/nu18111791
Kosiorz M, Muc-Wierzgoń M, Walkiewicz KW, Dzięgielewska-Gęsiak S. Post-Diagnostic Lifestyle Adaptations in Fibromyalgia: A Network and Cluster Analysis of Real-World Behavioral Patterns. Nutrients. 2026; 18(11):1791. https://doi.org/10.3390/nu18111791
Chicago/Turabian StyleKosiorz, Matylda, Małgorzata Muc-Wierzgoń, Katarzyna Weronika Walkiewicz, and Sylwia Dzięgielewska-Gęsiak. 2026. "Post-Diagnostic Lifestyle Adaptations in Fibromyalgia: A Network and Cluster Analysis of Real-World Behavioral Patterns" Nutrients 18, no. 11: 1791. https://doi.org/10.3390/nu18111791
APA StyleKosiorz, M., Muc-Wierzgoń, M., Walkiewicz, K. W., & Dzięgielewska-Gęsiak, S. (2026). Post-Diagnostic Lifestyle Adaptations in Fibromyalgia: A Network and Cluster Analysis of Real-World Behavioral Patterns. Nutrients, 18(11), 1791. https://doi.org/10.3390/nu18111791

