Next Article in Journal
Dynamic Variations in Endogenous Peptides in Chinese Human Milk Across Lactation and Geographical Regions
Previous Article in Journal
Short-Term Mediterranean Dietary Intervention Reduces Plasma Trimethylamine-N-Oxide Levels in Healthy Individuals
 
 
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Impact of Nutritional Status on Clinical Outcomes of Patients Undergoing PRGF Treatment for Knee Osteoarthritis—A Prospective Observational Study

1
IRCCS Ospedale Galeazzi Sant’Ambrogio, Orthopaedic Biotechnology Laboratory, 20157 Milan, Italy
2
Centro Diagnostico Italiano, Department of Clinical Laboratory, 20100 Milan, Italy
3
IRCCS Ospedale Galeazzi Sant’Ambrogio, Ortopedia Clinicizzata, 20157 Milan, Italy
4
Università degli Studi di Milano, Scienze Biomediche per la Salute, Medicina e Chirurgia, 20122 Milan, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2025, 17(19), 3134; https://doi.org/10.3390/nu17193134
Submission received: 26 August 2025 / Revised: 26 September 2025 / Accepted: 29 September 2025 / Published: 30 September 2025

Abstract

Background: Osteoarthritis (OA) is a major global health issue, increasing with aging and obesity. Current therapies mainly address symptoms without modifying disease progression. Platelet-rich growth factor (PRGF) therapy has potential regenerative effects through high cytokines and growth factors, but the outcomes of these therapies remain heterogeneous. This study explores the relationship between patient nutritional status, PRGF characteristics, and clinical outcomes in knee OA treatment. Methods: Baseline anthropometric, metabolic, and nutritional assessments of 41 patients with knee OA who underwent PRGF treatment were conducted. Blood samples were analyzed for metabolic and inflammatory markers. PRGF composition was assessed by protein content and extracellular vesicle (EV) markers. KOOS and VAS pain scores were collected at 2, 6, and 12 months. Responders improved KOOS by ≥10 points. An elastic-net regularized logistic model allowed the identification of the predictors of treatment response. Results: KOOS and VAS scores improved significantly at all follow-ups. At 2 months, the PRGF of responder patients showed higher PRGF G-CSF levels; at 12 months, increased CD49e and HLA-ABC expression. Higher BMI correlated with increased IL-6, IL-1ra, and resistin in PRGF samples. Hypercholesterolemic patients displayed altered EV profiles, with elevated levels of CD8 but reduced CD49e, HLA-ABC, CD42a, and CD31. Multivariate analysis identified BMI, biceps fold, fat percentage, red blood cell, platelet, and neutrophil counts as predictors of early response. Conclusions: Metabolic and immunological factors influence PRGF composition and clinical efficacy in knee OA. Baseline body composition and hematological parameters as key predictors of response, highlighting the potential of personalized PRGF therapy.
Keywords: osteoarthritis; platelet-rich growth factors; nutrition; BMI osteoarthritis; platelet-rich growth factors; nutrition; BMI

Share and Cite

MDPI and ACS Style

De Luca, P.; Grieco, G.; Landoni, S.; Caradonna, E.; Pascale, V.; Ragni, E.; de Girolamo, L. Impact of Nutritional Status on Clinical Outcomes of Patients Undergoing PRGF Treatment for Knee Osteoarthritis—A Prospective Observational Study. Nutrients 2025, 17, 3134. https://doi.org/10.3390/nu17193134

AMA Style

De Luca P, Grieco G, Landoni S, Caradonna E, Pascale V, Ragni E, de Girolamo L. Impact of Nutritional Status on Clinical Outcomes of Patients Undergoing PRGF Treatment for Knee Osteoarthritis—A Prospective Observational Study. Nutrients. 2025; 17(19):3134. https://doi.org/10.3390/nu17193134

Chicago/Turabian Style

De Luca, Paola, Giulio Grieco, Simona Landoni, Eugenio Caradonna, Valerio Pascale, Enrico Ragni, and Laura de Girolamo. 2025. "Impact of Nutritional Status on Clinical Outcomes of Patients Undergoing PRGF Treatment for Knee Osteoarthritis—A Prospective Observational Study" Nutrients 17, no. 19: 3134. https://doi.org/10.3390/nu17193134

APA Style

De Luca, P., Grieco, G., Landoni, S., Caradonna, E., Pascale, V., Ragni, E., & de Girolamo, L. (2025). Impact of Nutritional Status on Clinical Outcomes of Patients Undergoing PRGF Treatment for Knee Osteoarthritis—A Prospective Observational Study. Nutrients, 17(19), 3134. https://doi.org/10.3390/nu17193134

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop