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Article

Effect of Chronic Moderate Caloric Restriction on the Reproductive Function in Aged Male Wistar Rats

1
Doctorado en Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana, Ciudad de México 09340, Mexico
2
Departamento de Biología de la Reproducción, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de México 09340, Mexico
3
Unidad de Investigación en Gerontología, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, Ciudad de México 09230, Mexico
4
Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Hospital General de Zona No. 5, Puebla 74360, Mexico
5
Departamento de Investigación Básica, Instituto Nacional de Geriatría, Secretaria de Salud, Ciudad de México 10200, Mexico
*
Author to whom correspondence should be addressed.
Academic Editors: Marcellino Monda and Clare Marie Reynolds
Nutrients 2022, 14(6), 1256; https://doi.org/10.3390/nu14061256
Received: 3 January 2022 / Revised: 2 March 2022 / Accepted: 14 March 2022 / Published: 16 March 2022
(This article belongs to the Special Issue Diet and Fertility Status: Relevance in Health and Disease)
Caloric restriction (CR) has been shown to be an effective nutritional intervention for increasing longevity in some animal species. The objective of this study was to evaluate CR’s effects on metabolic and reproductive parameters in 12-month-old male Wistar rats. The rats were distributed in three groups: control, CR at 15%, and CR at 35% for 6 (up to 18 months of age) and 12 months (up to 24 months of age). At the end of CR treatment, we evaluated reproductive (male sexual behavior (MSB), sperm quality) and biochemical parameters (plasma glucose, glucose-regulating hormone, and sex steroid levels), and quantified annexin V in the seminiferous epithelium. Results showed that MSB and sperm quality were improved after 6 months of CR associated with increases in plasma testosterone and decrease annexin V in the seminiferous epithelium of the testicles compared to their control group. The metabolic profile of the CR rats also improved compared to controls. However, these effects of CR on reproductive parameters were not maintained after 12 months of CR. Findings suggest that beginning CR at the age of maturity reestablishes the behavioral sexual response and reproductive function in older animals after 6 months of CR and improves endocrine functioning during aging. View Full-Text
Keywords: calorie restriction; male sexual behavior; seminiferous tubules; testis; testosterone calorie restriction; male sexual behavior; seminiferous tubules; testis; testosterone
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MDPI and ACS Style

Jesús, P.L.d.; Arenas-Ríos, E.; Ruíz-Ramos, M.; Flores-Alonso, J.C.; Mendoza-Núñez, V.M.; Arrieta-Cruz, I.; Arteaga-Silva, M. Effect of Chronic Moderate Caloric Restriction on the Reproductive Function in Aged Male Wistar Rats. Nutrients 2022, 14, 1256. https://doi.org/10.3390/nu14061256

AMA Style

Jesús PLd, Arenas-Ríos E, Ruíz-Ramos M, Flores-Alonso JC, Mendoza-Núñez VM, Arrieta-Cruz I, Arteaga-Silva M. Effect of Chronic Moderate Caloric Restriction on the Reproductive Function in Aged Male Wistar Rats. Nutrients. 2022; 14(6):1256. https://doi.org/10.3390/nu14061256

Chicago/Turabian Style

Jesús, Pablo López de, Edith Arenas-Ríos, Mirna Ruíz-Ramos, Juan Carlos Flores-Alonso, Víctor Manuel Mendoza-Núñez, Isabel Arrieta-Cruz, and Marcela Arteaga-Silva. 2022. "Effect of Chronic Moderate Caloric Restriction on the Reproductive Function in Aged Male Wistar Rats" Nutrients 14, no. 6: 1256. https://doi.org/10.3390/nu14061256

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