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Article

Red-Fleshed Apples Rich in Anthocyanins and White-Fleshed Apples Modulate the Aorta and Heart Proteome in Hypercholesterolaemic Rats: The AppleCOR Study

1
Functional Nutrition, Oxidation, and CVD Research Group (NFOC-Salut), Medicine and Surgery Department, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili, 43201 Reus, Spain
2
Institut d’Investigació Sanitària Pere Virgili (IISPV), 43204 Reus, Spain
3
Unitat de Nutrició i Salut, Eurecat, Centre Tecnològic de Catalunya, 43204 Reus, Spain
4
Food Technology Department, Universitat de Lleida-AGROTECNIO Center, 25198 Lleida, Spain
5
Department of Medicine, Universitat de Lleida, 25008 Lleida, Spain
6
Institut de Recerca Biomèdica de Lleida, Fundació Dr. Pifarré-IRBLleida, 25198 Lleida, Spain
7
Eurecat, Centre Tecnològic de Catalunya, Centre for Omic Sciences (COS), Joint Unit Universitat Rovira i Virgili-EURECAT, 43204 Reus, Spain
8
Instituto de Ciencias de la Vid y del Vino (ICVV), Gobierno de La Rioja, CSIC, Universidad de La Rioja, 26007 Logroño, Spain
9
Hospital Universitari Sant Joan de Reus (HUSJR), 43204 Reus, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Paul Prenzler
Nutrients 2022, 14(5), 1047; https://doi.org/10.3390/nu14051047
Received: 13 January 2022 / Revised: 21 February 2022 / Accepted: 24 February 2022 / Published: 28 February 2022
(This article belongs to the Special Issue Bioactive Compounds in the Prevention of Hypertension)
The impact of a red-fleshed apple (RFA) rich in anthocyanins (ACNs), a white-fleshed apple (WFA) without ACNs, and an extract infusion from Aronia fruit (AI) equivalent in dose of cyanidin-3-O-galactoside (main ACN) as RFA was determined by the proteome profile of aorta and heart as key cardiovascular tissues. Hypercholesterolaemic Wistar rats were separated into six groups (n = 6/group; three males and three females) and the proteomic profiles were analyzed using nanoliquid chromatography coupled to mass spectrometry. No adverse events were reported and all products were well tolerated. RFA downregulated C1QB and CFP in aorta and CRP in heart. WFA downregulated C1QB and CFP in aorta and C9 and C3 in aorta and heart, among other proteins. AI downregulated PRKACA, IQGAP1, and HSP90AB1 related to cellular signaling. Thus, both apples showed an anti-inflammatory effect through the complement system, while RFA reduced CRP. Regardless of the ACN content, an apple matrix effect was observed that involved different bioactive components, and inflammatory proteins were reduced. View Full-Text
Keywords: anthocyanins; phenolic compounds; proteomics; aorta and heart rat tissues; apples anthocyanins; phenolic compounds; proteomics; aorta and heart rat tissues; apples
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MDPI and ACS Style

Catalán, Ú.; Pedret, A.; Yuste, S.; Rubió, L.; Piñol, C.; Sandoval-Ramírez, B.A.; Companys, J.; Foguet, E.; Herrero, P.; Canela, N.; Motilva, M.-J.; Solà, R. Red-Fleshed Apples Rich in Anthocyanins and White-Fleshed Apples Modulate the Aorta and Heart Proteome in Hypercholesterolaemic Rats: The AppleCOR Study. Nutrients 2022, 14, 1047. https://doi.org/10.3390/nu14051047

AMA Style

Catalán Ú, Pedret A, Yuste S, Rubió L, Piñol C, Sandoval-Ramírez BA, Companys J, Foguet E, Herrero P, Canela N, Motilva M-J, Solà R. Red-Fleshed Apples Rich in Anthocyanins and White-Fleshed Apples Modulate the Aorta and Heart Proteome in Hypercholesterolaemic Rats: The AppleCOR Study. Nutrients. 2022; 14(5):1047. https://doi.org/10.3390/nu14051047

Chicago/Turabian Style

Catalán, Úrsula, Anna Pedret, Silvia Yuste, Laura Rubió, Carme Piñol, Berner Andrée Sandoval-Ramírez, Judit Companys, Elisabet Foguet, Pol Herrero, Núria Canela, Maria-Jose Motilva, and Rosa Solà. 2022. "Red-Fleshed Apples Rich in Anthocyanins and White-Fleshed Apples Modulate the Aorta and Heart Proteome in Hypercholesterolaemic Rats: The AppleCOR Study" Nutrients 14, no. 5: 1047. https://doi.org/10.3390/nu14051047

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