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Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A Multi-Centre Population-Based Birth Cohort Study in Spain

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ISGlobal, 08003 Barcelona, Spain
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Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain
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Institut d’Investigació Sanitària Pere Virgili (IISPV), Hospital Universitari Sant Joan de Reus, 43204 Reus, Spain
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Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain
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Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, 28029 Madrid, Spain
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Instituto de Investigación Sanitaria y Biomédica de Alicante, Universidad Miguel Hernández (ISABIAL-UMH), 46020 Alicante, Spain
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Centro de Investigacion Biomedica en Red Epidemiologia y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
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Ministry of Health of the Basque Government, Sub-Directorate for Public Health and Addictions of Gipuzkoa, 20013 San Sebastian, Spain
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Group of Environmental Epidemiology and Child Development, Biodonostia Health Research Institute, 20014 San Sebastian, Spain
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Epidemiology and Environmental Health Joint Research Unit, FISABIO—Universitat Jaume I—Universitat de València, 46020 Valencia, Spain
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Universitat Rovira i Virgili (URV), Nutrition and Mental Health Research Group (NUTRISAM), 43201 Reus, Spain
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Universitat Rovira i Virgili (URV), Departament de Bioquímica i Biotecnologia, Unitat de Nutrició Humana, 43201 Reus, Spain
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Departamento de Medicina, Universidad de Oviedo, 33006 Oviedo, Spain
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IUOPA-ISPA, Avda. Hospital Universitario s/n, 33011 Oviedo, Spain
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Servicio de Pediatría, Endocrinología Pediátrica, HUCA, Roma Avenue S/n, 33001 Oviedo, Spain
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Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Centre, 3015 CN Rotterdam, The Netherlands
*
Author to whom correspondence should be addressed.
Academic Editor: Peter Pribis
Nutrients 2022, 14(3), 518; https://doi.org/10.3390/nu14030518
Received: 17 December 2021 / Revised: 17 January 2022 / Accepted: 20 January 2022 / Published: 25 January 2022
(This article belongs to the Section Lipids)
Background: There are few studies that look at the intake of all types of omega-3 polyunsaturated fatty acids (n-3 PUFAs) during the different stages of pregnancy along with a long-term neuropsychological follow-up of the child. This study aims to explore the association between maternal n-3 PUFA intake during two periods of pregnancy and the child’s neuropsychological scores at different ages. Methods: Prospective data were obtained for 2644 pregnant women recruited between 2004 and 2008 in population-based birth cohorts in Spain. Maternal n-3 PUFA intake during the first and third trimester of pregnancy was estimated using validated food frequency questionnaires. Child neuropsychological functions were assessed using Bayley Scales of Infant Development version one (BSID) at 1 year old, the McCarthy Scale of Children’s Abilities (MSCA) at 4 years old, and the Attention Network Test (ANT) at 7 years old. Data were analysed using multivariate linear regression models and adjusted for potential covariates, such as maternal social class, education, cohort location, alcohol consumption, smoking, breastfeeding duration, and energy intake. Results: Compared to participants in the lowest quartile (<1.262 g/day) of n-3 PUFA consumption during the first trimester, those in the highest quartile (>1.657 g/day) had a 2.26 points (95% confidence interval (CI): 0.41, 4.11) higher MSCA general cognitive score, a 2.48 points (95% CI: 0.53, 4.43) higher MSCA verbal score, and a 2.06 points (95% CI: 0.166, 3.95) higher MSCA executive function score, and a 11.52 milliseconds (95% CI: −22.95, −0.09) lower ANT hit reaction time standard error. In the third pregnancy trimester, the associations were weaker. Conclusions: Positive associations between n-3 PUFA intake during early pregnancy and child neuropsychological functions at 4 and 7 years of age were found, and further clinical research is needed to confirm these findings. View Full-Text
Keywords: maternal diet; children; neurodevelopment; omega-3 fatty acids; population-based cohort maternal diet; children; neurodevelopment; omega-3 fatty acids; population-based cohort
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MDPI and ACS Style

Tahaei, H.; Gignac, F.; Pinar, A.; Fernandez-Barrés, S.; Romaguera, D.; Vioque, J.; Santa-Marina, L.; Subiza-Pérez, M.; Llop, S.; Soler-Blasco, R.; Arija, V.; Salas-Salvadó, J.; Tardón, A.; Riaño-Galán, I.; Sunyer, J.; Guxens, M.; Julvez, J. Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A Multi-Centre Population-Based Birth Cohort Study in Spain. Nutrients 2022, 14, 518. https://doi.org/10.3390/nu14030518

AMA Style

Tahaei H, Gignac F, Pinar A, Fernandez-Barrés S, Romaguera D, Vioque J, Santa-Marina L, Subiza-Pérez M, Llop S, Soler-Blasco R, Arija V, Salas-Salvadó J, Tardón A, Riaño-Galán I, Sunyer J, Guxens M, Julvez J. Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A Multi-Centre Population-Based Birth Cohort Study in Spain. Nutrients. 2022; 14(3):518. https://doi.org/10.3390/nu14030518

Chicago/Turabian Style

Tahaei, Hana, Florence Gignac, Ariadna Pinar, Silvia Fernandez-Barrés, Dora Romaguera, Jesus Vioque, Loreto Santa-Marina, Mikel Subiza-Pérez, Sabrina Llop, Raquel Soler-Blasco, Victoria Arija, Jordi Salas-Salvadó, Adonina Tardón, Isolina Riaño-Galán, Jordi Sunyer, Monica Guxens, and Jordi Julvez. 2022. "Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A Multi-Centre Population-Based Birth Cohort Study in Spain" Nutrients 14, no. 3: 518. https://doi.org/10.3390/nu14030518

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