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Article

Insight on Glucose and Fructose Absorption and Relevance in the Enterocyte Milieu

1
Department of Agri-Food Sciences and Technologies (DISTAL), University of Bologna, Piazza Goidanich 60, 47521 Cesena, Italy
2
Department of Food, Environmental and Nutritional Sciences (Defens), University of Milan, via Celoria 2, 20133 Milan, Italy
3
Interdepartmental Centre for Industrial Agri-Food Research (CIRI), University of Bologna, Piazza Goidanich 60, 47521 Cesena, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: David J. Mela and Daniel Lamport
Nutrients 2022, 14(3), 517; https://doi.org/10.3390/nu14030517
Received: 18 November 2021 / Revised: 10 January 2022 / Accepted: 20 January 2022 / Published: 25 January 2022
(This article belongs to the Section Carbohydrates)
Although epidemiological studies indicate a strong correlation between high sugar intake and metabolic diseases, the biological mechanisms underlying this link are still controversial. To further examine the modification and crosstalk occurring in enterocyte metabolism during sugar absorption, in this study we evaluate the diffusion and intestinal metabolism of glucose, fructose and sucrose, which were supplemented in equimolar concentration to Caco-2 cells grown on polyester membrane inserts. At different time points after supplementation, changes in metabolite concentration were evaluated in the apical and basolateral chambers by nuclear magnetic resonance (NMR) and gas-chromatography (GC). Sucrose was only minimally hydrolyzed by Caco-2 cells. Upon supplementation, we observed a faster uptake of fructose than glucose, the pentose sugar being also faster catabolized. Monosaccharide absorption was concomitant to the synthesis/transport of other metabolites, which occurred differently in glucose and fructose supplemented cells. Our results confirm the prominent role of intestinal cells in fructose metabolism and clearance after absorption, representing a further step forward in the understanding of the role of dietary sugars. Future research, including targeted analysis on specific transporters/enzymes and the use of labeled substrates, will be helpful to confirm the present results and their interpretation. View Full-Text
Keywords: fructose; glucose; enterocytes fructose; glucose; enterocytes
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MDPI and ACS Style

Chiarello, E.; Di Nunzio, M.; Picone, G.; Antonelli, G.; Capozzi, F.; Bordoni, A. Insight on Glucose and Fructose Absorption and Relevance in the Enterocyte Milieu. Nutrients 2022, 14, 517. https://doi.org/10.3390/nu14030517

AMA Style

Chiarello E, Di Nunzio M, Picone G, Antonelli G, Capozzi F, Bordoni A. Insight on Glucose and Fructose Absorption and Relevance in the Enterocyte Milieu. Nutrients. 2022; 14(3):517. https://doi.org/10.3390/nu14030517

Chicago/Turabian Style

Chiarello, Elena, Mattia Di Nunzio, Gianfranco Picone, Giorgia Antonelli, Francesco Capozzi, and Alessandra Bordoni. 2022. "Insight on Glucose and Fructose Absorption and Relevance in the Enterocyte Milieu" Nutrients 14, no. 3: 517. https://doi.org/10.3390/nu14030517

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