Next Article in Journal
Late-Night Overeating or Low-Quality Food Choices Late at Night Are Associated with Subclinical Vascular Damage in Patients at Increased Cardiovascular Risk
Next Article in Special Issue
Diet, Sun, Physical Activity and Vitamin D Status in Children with Inflammatory Bowel Disease
Previous Article in Journal
Breast Cancer Diet “BCD”: A Review of Healthy Dietary Patterns to Prevent Breast Cancer Recurrence and Reduce Mortality
Previous Article in Special Issue
Interaction between Dietary Fat Intake and Metabolic Genetic Risk Score on 25-Hydroxyvitamin D Concentrations in a Turkish Adult Population
Review

The Immunologic Profile of Vitamin D and Its Role in Different Immune-Mediated Diseases: An Expert Opinion

1
Clinica Medica 1, Department of Medicine, University of Padova, 35128 Padova, Italy
2
Metabolic Bone Disease Unit & Fracture Liaison Service, Department of Medical Specialties, Regional Health Trust 3, 16125 Genova, Italy
3
Department of Clinical, Internal, Anaesthesiology, and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy
4
Division of Endocrinology and Diabetes, Universita Campus Bio-Medico di Roma, 00128 Rome, Italy
5
Unit of Clinica e Terapia Medica, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy
6
Rheumatology Unit, Department of Medicine, University of Verona, 37134 Verona, Italy
7
Division of Rheumatology, ASST Gaetano Pini-CTO, 20122 Milano, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Edgard Delvin
Nutrients 2022, 14(3), 473; https://doi.org/10.3390/nu14030473
Received: 20 December 2021 / Revised: 11 January 2022 / Accepted: 18 January 2022 / Published: 21 January 2022
(This article belongs to the Special Issue Benefits of Vitamin D in Health and Diseases)
Historically, vitamin D is recognized as an essential component for the maintenance of the musculoskeletal system. The immunomodulatory role of vitamin D in health and disease has gained much interest in recent years due to the many pathologies that share underlying immunological features where vitamin D has been shown to exert a potential role. Evidence from pre-clinical studies show that vitamin D elicits biological effects on both the innate and adaptive immune systems. Furthermore, in vivo studies have shown that administration of vitamin D can lead to changes in or the development of a range of immune-related diseases. This encourages the hypothesis that data derived from clinical and epidemiological studies connect vitamin D with the incidence and severity of many immune-mediated disorders such as rheumatoid arthritis, diabetes, and infectious diseases. Since some other immune-mediated diseases share similar features to that of viral infection such as COVID-19, in this review, we examined these other areas and the role of vitamin D in these diseases. View Full-Text
Keywords: vitamin D; immune-mediated disease; cholecalciferol; COVID-19 vitamin D; immune-mediated disease; cholecalciferol; COVID-19
MDPI and ACS Style

Giannini, S.; Giusti, A.; Minisola, S.; Napoli, N.; Passeri, G.; Rossini, M.; Sinigaglia, L. The Immunologic Profile of Vitamin D and Its Role in Different Immune-Mediated Diseases: An Expert Opinion. Nutrients 2022, 14, 473. https://doi.org/10.3390/nu14030473

AMA Style

Giannini S, Giusti A, Minisola S, Napoli N, Passeri G, Rossini M, Sinigaglia L. The Immunologic Profile of Vitamin D and Its Role in Different Immune-Mediated Diseases: An Expert Opinion. Nutrients. 2022; 14(3):473. https://doi.org/10.3390/nu14030473

Chicago/Turabian Style

Giannini, Sandro, Andrea Giusti, Salvatore Minisola, Nicola Napoli, Giovanni Passeri, Maurizio Rossini, and Luigi Sinigaglia. 2022. "The Immunologic Profile of Vitamin D and Its Role in Different Immune-Mediated Diseases: An Expert Opinion" Nutrients 14, no. 3: 473. https://doi.org/10.3390/nu14030473

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop