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Nutrients
Volume 14
Issue 17
10.3390/nu14173580
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Article
Peer-Review Record

Vitamin D Status in Critically Ill Patients with SIRS and Its Relationship with Circulating Zn and Related Parameters during ICU Stay

Nutrients 2022, 14(17), 3580; https://doi.org/10.3390/nu14173580
by Lourdes Herrera-Quintana 1, Héctor Vázquez-Lorente 1,*, Jorge Molina-López 2,*, Yenifer Gamarra-Morales 1, Javier Ignacio Martín-López 3 and Elena Planells 1
Reviewer 2:
Yawen Zeng
Nutrients 2022, 14(17), 3580; https://doi.org/10.3390/nu14173580
Submission received: 16 August 2022 / Revised: 26 August 2022 / Accepted: 27 August 2022 / Published: 30 August 2022
(This article belongs to the Special Issue Nutrition and Critical Illness)

Round 1

Reviewer 1 Report

The article needs improvement.

1. Add subchapter title Analytical determination of vitamin Zn. The subsection describing the methodologies for determining Zn.

2. Line 137 correct unit to ° C.

3. Verse 141 quotation of literature should be at the end of the sentence.

4. Verse 247quotation of literature should be at the end of the sentence.

5. Verse 260 quotation of literature should be at the end of the sentence.

6. Verse 141 quotation of literature should be at the end of the sentence.

7. Verse 276 quotation of literature should be at the end of the sentence.

8. Verse 277 quotation of literature should be at the end of the sentence.

9. Verse 278  quotation of literature should be at the end of the sentence.

10. Verse 314 correct the entry 1,25-OH2-D.

Author Response

Please see the attachment

Author Response File: Author Response.docx

Reviewer 2 Report

Critically ill patients  generate systemic inflammatory response syndrome that vitamin D or Zn could be crucial in patients' recovery. The paper reveals that  an interaction between vitamin D and Zn, being a correct status of these micronutrients a potentially modifiable factor and beneficial approach in critical ill patients' recovery.  This paper has great theoretical significance and high practical value for the nutritional structure improvement in critically ill patients. The analysis process is comprehensive and the article is organized, smooth language and so on. Major revision can be published in Nutrients. However, there are some major issues need to be improved:

1. Abstract: The abstract should be modified to enhance the readability;

2. Introduction: Recent references on foods with high vitamin D and Zn content to increase readership;

3. Materials and Methods: Nutritional profile, whether it can be clearly specific?

4. Results: Can you supplement the role in the nutritional formula vitamin D and Zn?

5. Discussion: Can we supplement the vitamin D and Zn effect in food?

Author Response

Please see the attachment

Author Response File: Author Response.docx

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