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Review

Polyphenols—Gut Microbiota Interrelationship: A Transition to a New Generation of Prebiotics

1
Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, Calea Mănăștur 3-5, 400372 Cluj-Napoca, Romania
2
Institute of Life Sciences, University of Agricultural Sciences and Veterinary Medicine, Calea Mănăștur 3-5, 400372 Cluj-Napoca, Romania
*
Author to whom correspondence should be addressed.
Academic Editor: Manuel Sánchez Santos
Nutrients 2022, 14(1), 137; https://doi.org/10.3390/nu14010137
Received: 5 December 2021 / Revised: 21 December 2021 / Accepted: 24 December 2021 / Published: 28 December 2021
(This article belongs to the Section Phytochemicals and Human Health)
The present review summarizes the studies carried out on this topic in the last five years. According to the new definitions, among all the compounds included in the group of prebiotics, polyphenols are probably the most important secondary metabolites produced by the plant kingdom. Many of these types of polyphenols have low bioavailability, therefore reaching the colon in unaltered form. Once in the colon, these compounds interact with the intestinal microbes bidirectionally by modulating them and, consequently, releasing metabolites. Despite much research on various metabolites, little is known about the chemistry of the metabolic routes used by different bacteria species. In this context, this review aims to investigate the prebiotic effect of polyphenols in preclinical and clinical studies, highlighting that the consumption of polyphenols leads to an increase in beneficial bacteria, as well as an increase in the production of valuable metabolites. In conclusion, there is much evidence in preclinical studies supporting the prebiotic effect of polyphenols, but further clinical studies are needed to investigate this effect in humans. View Full-Text
Keywords: polyphenols; prebiotics; gut microbiota; bioactive compounds; bacteria polyphenols; prebiotics; gut microbiota; bioactive compounds; bacteria
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MDPI and ACS Style

Plamada, D.; Vodnar, D.C. Polyphenols—Gut Microbiota Interrelationship: A Transition to a New Generation of Prebiotics. Nutrients 2022, 14, 137. https://doi.org/10.3390/nu14010137

AMA Style

Plamada D, Vodnar DC. Polyphenols—Gut Microbiota Interrelationship: A Transition to a New Generation of Prebiotics. Nutrients. 2022; 14(1):137. https://doi.org/10.3390/nu14010137

Chicago/Turabian Style

Plamada, Diana, and Dan Cristian Vodnar. 2022. "Polyphenols—Gut Microbiota Interrelationship: A Transition to a New Generation of Prebiotics" Nutrients 14, no. 1: 137. https://doi.org/10.3390/nu14010137

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