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Nutrients
Volume 13
Issue 8
10.3390/nu13082902
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Article

Weight Change in Post-Menopausal Women with Breast Cancer during Chemotherapy—Perspectives on Nutrition, Activity and Bone Metabolism: An Interim Analysis of a 5-Year Prospective Cohort

by
Kristian Buch-Larsen
1,*,
Trine Lund-Jacobsen
1,
Michael Andersson
2 and
Peter Schwarz
1,3
1
Department of Endocrinology and Metabolism, Rigshospitalet, 2100 Copenhagen, Denmark
2
Department of Oncology, Rigshospitalet, 2100 Copenhagen, Denmark
3
Faculty of Health Sciences, University of Copenhagen, 2100 Copenhagen, Denmark
*
Author to whom correspondence should be addressed.
Nutrients 2021, 13(8), 2902; https://doi.org/10.3390/nu13082902
Submission received: 5 August 2021 / Revised: 19 August 2021 / Accepted: 21 August 2021 / Published: 23 August 2021
(This article belongs to the Special Issue Osteoporosis and Elderly Metabolism and Nutrition)
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Abstract

Women with breast cancer are a growing population due to improved screening and treatment. It has been described that chemotherapy can negatively affect patients’ metabolism. The aim of this study is to assess weight gain during chemotherapy treatment in an interim analysis on an ongoing prospective cohort of women with early breast cancer. To help untangle the many possible reasons for weight change, we examine blood tests, Patient-Reported Outcomes (PROs), and bone mineral density (BMD). We find that the 38 women that have measurements taken after chemotherapy have an average weight gain of 1.2 kg although not significant. Together with this, there is a significant drop in HDL cholesterol, an increase in triglycerides, and a non-significant tendency towards decreased insulin sensitivity. PROs show that although the women experience more pain and fatigue, they have higher activity levels. BMD is at an expected level according to age. All in all, we see an increased focus on physical activity and nutrition, leading to less severe metabolic changes as previously reported. However, even though more measures are taken, we still see an overall negative metabolic impact with unknown long-term implications.
Keywords: breast cancer; metabolism; body weight; chemotherapy; nutrition; exercise; patient-reported outcomes breast cancer; metabolism; body weight; chemotherapy; nutrition; exercise; patient-reported outcomes

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MDPI and ACS Style

Buch-Larsen, K.; Lund-Jacobsen, T.; Andersson, M.; Schwarz, P. Weight Change in Post-Menopausal Women with Breast Cancer during Chemotherapy—Perspectives on Nutrition, Activity and Bone Metabolism: An Interim Analysis of a 5-Year Prospective Cohort. Nutrients 2021, 13, 2902. https://doi.org/10.3390/nu13082902

AMA Style

Buch-Larsen K, Lund-Jacobsen T, Andersson M, Schwarz P. Weight Change in Post-Menopausal Women with Breast Cancer during Chemotherapy—Perspectives on Nutrition, Activity and Bone Metabolism: An Interim Analysis of a 5-Year Prospective Cohort. Nutrients. 2021; 13(8):2902. https://doi.org/10.3390/nu13082902

Chicago/Turabian Style

Buch-Larsen, Kristian, Trine Lund-Jacobsen, Michael Andersson, and Peter Schwarz. 2021. "Weight Change in Post-Menopausal Women with Breast Cancer during Chemotherapy—Perspectives on Nutrition, Activity and Bone Metabolism: An Interim Analysis of a 5-Year Prospective Cohort" Nutrients 13, no. 8: 2902. https://doi.org/10.3390/nu13082902

APA Style

Buch-Larsen, K., Lund-Jacobsen, T., Andersson, M., & Schwarz, P. (2021). Weight Change in Post-Menopausal Women with Breast Cancer during Chemotherapy—Perspectives on Nutrition, Activity and Bone Metabolism: An Interim Analysis of a 5-Year Prospective Cohort. Nutrients, 13(8), 2902. https://doi.org/10.3390/nu13082902

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