Next Article in Journal
Effects of High Intensity Dynamic Resistance Exercise and Whey Protein Supplements on Osteosarcopenia in Older Men with Low Bone and Muscle Mass. Final Results of the Randomized Controlled FrOST Study
Next Article in Special Issue
Choline Intake as Supplement or as a Component of Eggs Increases Plasma Choline and Reduces Interleukin-6 without Modifying Plasma Cholesterol in Participants with Metabolic Syndrome
Previous Article in Journal
Reply to “Comparisons of Within-Group Instead of Between-Group Affect the Conclusions. Comment on: Changes in Weight and Substrate Oxidation in Overweight Adults Following Isomaltulose Intake during a 12-Week Weight Loss Intervention: A Randomized, Double-Blind, Controlled Trial. Nutrients 2019, 11(10), 2367”
Previous Article in Special Issue
Choline: An Essential Nutrient for Skeletal Muscle
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Nutrients
Volume 12
Issue 8
10.3390/nu12082340
nutrients-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

The Relationship between Choline Bioavailability from Diet, Intestinal Microbiota Composition, and Its Modulation of Human Diseases

by
Natalia Arias
1,2,*,
Silvia Arboleya
3,
Joseph Allison
2,
Aleksandra Kaliszewska
2,
Sara G. Higarza
1,4,
Miguel Gueimonde
3 and
Jorge L. Arias
1,4
1
Instituto de Neurociencias del Principado de Asturias (INEUROPA), 33003 Oviedo, Asturias, Spain
2
Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, Denmark Hill, London SE5 8AF, UK
3
Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias (IPLA-CSIC), 33003 Oviedo, Asturias, Spain
4
Laboratory of Neuroscience, Department of Psychology, University of Oviedo, Plaza Feijóo, s/n, 33003 Oviedo, Asturias, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(8), 2340; https://doi.org/10.3390/nu12082340
Submission received: 14 July 2020 / Revised: 28 July 2020 / Accepted: 30 July 2020 / Published: 5 August 2020
(This article belongs to the Special Issue Choline: An Essential Nutrient for Human Health)
Browse Figures
Versions Notes

Abstract

Choline is a water-soluble nutrient essential for human life. Gut microbial metabolism of choline results in the production of trimethylamine (TMA), which, upon absorption by the host is converted into trimethylamine-N-oxide (TMAO) in the liver. A high accumulation of both components is related to cardiovascular disease, inflammatory bowel disease, non-alcoholic fatty liver disease, and chronic kidney disease. However, the relationship between the microbiota production of these components and its impact on these diseases still remains unknown. In this review, we will address which microbes contribute to TMA production in the human gut, the extent to which host factors (e.g., the genotype) and diet affect TMA production, and the colonization of these microbes and the reversal of dysbiosis as a therapy for these diseases.
Keywords: choline; TMA; TMAO; non-alcoholic steatohepatitis (NASH); cardiovascular disease (CVD); chronic kidney diseases (CKD); probiotics; gut microbiota; polyphenols; fecal microbiota transplantation choline; TMA; TMAO; non-alcoholic steatohepatitis (NASH); cardiovascular disease (CVD); chronic kidney diseases (CKD); probiotics; gut microbiota; polyphenols; fecal microbiota transplantation

Share and Cite

MDPI and ACS Style

Arias, N.; Arboleya, S.; Allison, J.; Kaliszewska, A.; Higarza, S.G.; Gueimonde, M.; Arias, J.L. The Relationship between Choline Bioavailability from Diet, Intestinal Microbiota Composition, and Its Modulation of Human Diseases. Nutrients 2020, 12, 2340. https://doi.org/10.3390/nu12082340

AMA Style

Arias N, Arboleya S, Allison J, Kaliszewska A, Higarza SG, Gueimonde M, Arias JL. The Relationship between Choline Bioavailability from Diet, Intestinal Microbiota Composition, and Its Modulation of Human Diseases. Nutrients. 2020; 12(8):2340. https://doi.org/10.3390/nu12082340

Chicago/Turabian Style

Arias, Natalia, Silvia Arboleya, Joseph Allison, Aleksandra Kaliszewska, Sara G. Higarza, Miguel Gueimonde, and Jorge L. Arias. 2020. "The Relationship between Choline Bioavailability from Diet, Intestinal Microbiota Composition, and Its Modulation of Human Diseases" Nutrients 12, no. 8: 2340. https://doi.org/10.3390/nu12082340

APA Style

Arias, N., Arboleya, S., Allison, J., Kaliszewska, A., Higarza, S. G., Gueimonde, M., & Arias, J. L. (2020). The Relationship between Choline Bioavailability from Diet, Intestinal Microbiota Composition, and Its Modulation of Human Diseases. Nutrients, 12(8), 2340. https://doi.org/10.3390/nu12082340

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop