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Chronic Supplementation with a Mix of Salvia officinalis and Salvia lavandulaefolia Improves Morris Water Maze Learning in Normal Adult C57Bl/6J Mice

1
Université de Bordeaux, INRAE, Bordeaux INP, NutriNeuro laboratory, 146 rue Léo Saignat, 33076 Bordeaux, France
2
NutriBrain Research and Technology Transfer, Nutrition et Neurobiologie Intégrée, UMR 1286, 33076 Bordeaux, France
3
Nexira, 129 Chemin de Croisset, 76000 Rouen, France
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(6), 1777; https://doi.org/10.3390/nu12061777
Received: 20 April 2020 / Revised: 9 June 2020 / Accepted: 11 June 2020 / Published: 15 June 2020
(This article belongs to the Section Nutrition and Metabolism)
Background: Two different species of sage, Salvia officinalis and Salvia lavandulaefolia, have demonstrated activities in cognitive function during preclinical and clinical studies related to impaired health situations or single administration. Different memory processes have been described to be significantly and positively impacted. Objective: Our objective is to explore the potential of these Salvia, and their additional activities, in healthy situations, and during prolonged administration, on memory and subsequent mechanisms of action related to putative effects. Design: This mouse study has implicated four investigational arms dedicated to control, Salvia officinalis aqueous extract, Salvia lavandulaefolia-encapsulated essential oil and a mix thereof (Cognivia™) for 2 weeks of administration. Cognitive functions have been assessed throughout Y-maze and Morris water maze models. The impact of supplementation on lipid peroxidation, oxidative stress, neurogenesis, neuronal activity, neurotrophins, neurotrophin receptors, CaM kinase II and glucocorticoid receptors has been assessed via post-interventional tissue collection. Results: All Salvia groups had a significant effect on Y-maze markers on day 1 of administration. Only the mix of two Salvia species demonstrated significant improvements in Morris water maze markers at the end of administration. Considering all biological and histological markers, we did not observe any significant effect of S. officinalis, S. lavandulaefolia and a mix of Salvia supplementation on lipid peroxidation, oxidative stress and neuronal plasticity (neurogenesis, neuronal activity, neurotrophins). Interestingly, CaM kinase II protein expression is significantly increased in animals supplemented with Salvia. Conclusion: The activities of Salvia alone after one intake have been confirmed; however, a particular combination of different types of Salvia have been shown to improve memory and present specific synergistic effects after chronic administration in healthy mice. View Full-Text
Keywords: Salvia officinalis; Salvia lavandulaefolia; cognition; short-term memory; CaMKII; spatial memory; navigation strategies Salvia officinalis; Salvia lavandulaefolia; cognition; short-term memory; CaMKII; spatial memory; navigation strategies
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MDPI and ACS Style

Dinel, A.-L.; Lucas, C.; Guillemet, D.; Layé, S.; Pallet, V.; Joffre, C. Chronic Supplementation with a Mix of Salvia officinalis and Salvia lavandulaefolia Improves Morris Water Maze Learning in Normal Adult C57Bl/6J Mice. Nutrients 2020, 12, 1777. https://doi.org/10.3390/nu12061777

AMA Style

Dinel A-L, Lucas C, Guillemet D, Layé S, Pallet V, Joffre C. Chronic Supplementation with a Mix of Salvia officinalis and Salvia lavandulaefolia Improves Morris Water Maze Learning in Normal Adult C57Bl/6J Mice. Nutrients. 2020; 12(6):1777. https://doi.org/10.3390/nu12061777

Chicago/Turabian Style

Dinel, Anne-Laure; Lucas, Céline; Guillemet, Damien; Layé, Sophie; Pallet, Véronique; Joffre, Corinne. 2020. "Chronic Supplementation with a Mix of Salvia officinalis and Salvia lavandulaefolia Improves Morris Water Maze Learning in Normal Adult C57Bl/6J Mice" Nutrients 12, no. 6: 1777. https://doi.org/10.3390/nu12061777

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