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The Effect of Natural Antioxidants in the Development of Metabolic Syndrome: Focus on Bergamot Polyphenolic Fraction

Institute of Research for Food Safety & Health IRC-FSH, University Magna Graecia, 88100 Catanzaro, Italy
Department of Medicine, Chair of Cardiology, University of Rome Tor Vergata, 00133 Roma, Italy
Nutramed S.c.a.r.l., Complesso Ninì Barbieri, Roccelletta di Borgia, 88021 Catanzaro, Italy
IRCCS San Raffaele Pisana, 00163 Roma, Italy
Author to whom correspondence should be addressed.
Nutrients 2020, 12(5), 1504;
Received: 22 March 2020 / Revised: 14 May 2020 / Accepted: 15 May 2020 / Published: 21 May 2020
(This article belongs to the Special Issue Diets, Foods and Food Components Effect on Dyslipidemia)
Metabolic syndrome (MetS) represents a set of clinical findings that include visceral adiposity, insulin-resistance, high triglycerides (TG), low high-density lipoprotein cholesterol (HDL-C) levels and hypertension, which is linked to an increased risk of developing type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular disease (ASCVD). The pathogenesis of MetS involves both genetic and acquired factors triggering oxidative stress, cellular dysfunction and systemic inflammation process mainly responsible for the pathophysiological mechanism. In recent years, MetS has gained importance due to the exponential increase in obesity worldwide. However, at present, it remains underdiagnosed and undertreated. The present review will summarize the pathogenesis of MetS and the existing pharmacological therapies currently used and focus attention on the beneficial effects of natural compounds to reduce the risk and progression of MetS. In this regard, emerging evidence suggests a potential protective role of bergamot extracts, in particular bergamot flavonoids, in the management of different features of MetS, due to their pleiotropic anti-oxidative, anti-inflammatory and lipid-lowering effects. View Full-Text
Keywords: metabolic syndrome; plant extracts; natural antioxidant; polyphenols; bergamot metabolic syndrome; plant extracts; natural antioxidant; polyphenols; bergamot
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Carresi, C.; Gliozzi, M.; Musolino, V.; Scicchitano, M.; Scarano, F.; Bosco, F.; Nucera, S.; Maiuolo, J.; Macrì, R.; Ruga, S.; Oppedisano, F.; Zito, M.C.; Guarnieri, L.; Mollace, R.; Tavernese, A.; Palma, E.; Bombardelli, E.; Fini, M.; Mollace, V. The Effect of Natural Antioxidants in the Development of Metabolic Syndrome: Focus on Bergamot Polyphenolic Fraction. Nutrients 2020, 12, 1504.

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