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Open AccessArticle

Administration of Apple Polyphenol Supplements for Skin Conditions in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

1
Research Laboratories for Fundamental Technology of Food, Asahi Breweries Ltd., 1-21 Midori 1-chome, Moriya-shi, Ibaraki 305-0106, Japan
2
Food Research Institute, National Agriculture and Food Research Organization, 2-1-12 Kannondai, Tsukuba-shi, Ibaraki 305–8605, Japan
3
Faculty of Food and Agricultural Sciences, Fukushima University, 1 Kanayagawa, Fukushima-shi, Fukushima 960-1269, Japan
4
Asahi Group Foods, Ltd., 2-4-1 Ebisuminami, Shibuya-ku, Tokyo 150-0022, Japan
5
Asahi Group Holdings Ltd., 1-21 Midori 1-chome, Moriya-shi, Ibaraki 305-0106, Japan
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(4), 1071; https://doi.org/10.3390/nu12041071
Received: 27 March 2020 / Revised: 7 April 2020 / Accepted: 9 April 2020 / Published: 13 April 2020
(This article belongs to the Section Phytochemicals and Human Health)
This clinical study was performed to evaluate the effects of continuous apple polyphenol (AP) administration on facial skin conditions and pigmentation induced by ultraviolet (UV) irradiation in healthy women participants. Participants (n = 65, age 20–39 years) were randomized to receive tablets containing AP (300 or 600 mg/day) or placebo in a double-blinded, placebo-controlled clinical trial. Continuous administration of AP for 12 weeks significantly prevented UV irradiation induced skin pigmentation (erythema value, melanin value, L value), although a dose-dependent relationship was not clearly observed. In contrast, no significant differences were detected between the groups with regard to water content and trans-epidermal water loss. Our study demonstrated that APs and their major active compounds, procyanidins, have several health benefits. Here, we report that continuous administration of AP for 12 weeks alleviated UV irradiation induced skin pigmentation, when compared with placebo, in healthy women. View Full-Text
Keywords: Apple polyphenols; procyanidin; UV irradiation; skin condition; pigmentation Apple polyphenols; procyanidin; UV irradiation; skin condition; pigmentation
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Shoji, T.; Masumoto, S.; Moriichi, N.; Ohtake, Y.; Kanda, T. Administration of Apple Polyphenol Supplements for Skin Conditions in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients 2020, 12, 1071.

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