Administration of Apple Polyphenol Supplements for Skin Conditions in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Shoji, Toshihiko; Masumoto, Saeko; Moriichi, Nina; Ohtake, Yasuyuki; Kanda, Tomomasa

doi:10.3390/nu12041071

Submit to this Journal Review for this Journal Edit a Special Issue

Article Menu

...

Open AccessArticle

Administration of Apple Polyphenol Supplements for Skin Conditions in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

^1,2,*

^1,3,

¹,

^1,4 and

^1,5

Research Laboratories for Fundamental Technology of Food, Asahi Breweries Ltd., 1-21 Midori 1-chome, Moriya-shi, Ibaraki 305-0106, Japan

Food Research Institute, National Agriculture and Food Research Organization, 2-1-12 Kannondai, Tsukuba-shi, Ibaraki 305–8605, Japan

Faculty of Food and Agricultural Sciences, Fukushima University, 1 Kanayagawa, Fukushima-shi, Fukushima 960-1269, Japan

⁴

Asahi Group Foods, Ltd., 2-4-1 Ebisuminami, Shibuya-ku, Tokyo 150-0022, Japan

⁵

Asahi Group Holdings Ltd., 1-21 Midori 1-chome, Moriya-shi, Ibaraki 305-0106, Japan

Author to whom correspondence should be addressed.

Nutrients 2020, 12(4), 1071; https://doi.org/10.3390/nu12041071

Received: 27 March 2020 / Revised: 7 April 2020 / Accepted: 9 April 2020 / Published: 13 April 2020

(This article belongs to the Section Phytochemicals and Human Health)

View Full-Text Download PDF

Browse Figures

Citation Export

Abstract

This clinical study was performed to evaluate the effects of continuous apple polyphenol (AP) administration on facial skin conditions and pigmentation induced by ultraviolet (UV) irradiation in healthy women participants. Participants (n = 65, age 20–39 years) were randomized to receive tablets containing AP (300 or 600 mg/day) or placebo in a double-blinded, placebo-controlled clinical trial. Continuous administration of AP for 12 weeks significantly prevented UV irradiation induced skin pigmentation (erythema value, melanin value, L value), although a dose-dependent relationship was not clearly observed. In contrast, no significant differences were detected between the groups with regard to water content and trans-epidermal water loss. Our study demonstrated that APs and their major active compounds, procyanidins, have several health benefits. Here, we report that continuous administration of AP for 12 weeks alleviated UV irradiation induced skin pigmentation, when compared with placebo, in healthy women. View Full-Text

Keywords: Apple polyphenols; procyanidin; UV irradiation; skin condition; pigmentation

▼ Show Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Supplementary Material

Supplementary File 1:
PPTX-Document (PPTX, 121 KiB)

Share and Cite

MDPI and ACS Style

Shoji, T.; Masumoto, S.; Moriichi, N.; Ohtake, Y.; Kanda, T. Administration of Apple Polyphenol Supplements for Skin Conditions in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients 2020, 12, 1071. https://doi.org/10.3390/nu12041071

AMA Style

Shoji T, Masumoto S, Moriichi N, Ohtake Y, Kanda T. Administration of Apple Polyphenol Supplements for Skin Conditions in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients. 2020; 12(4):1071. https://doi.org/10.3390/nu12041071

Chicago/Turabian Style

Shoji, Toshihiko, Saeko Masumoto, Nina Moriichi, Yasuyuki Ohtake, and Tomomasa Kanda. 2020. "Administration of Apple Polyphenol Supplements for Skin Conditions in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial" Nutrients 12, no. 4: 1071. https://doi.org/10.3390/nu12041071

Find Other Styles

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Abstract views Pdf views Html views

Article Menu

Administration of Apple Polyphenol Supplements for Skin Conditions in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Abstract

Supplementary Material

Share and Cite

Article Metrics

Article Access Statistics

Article Access Map by Country/Region

Further Information

Guidelines

MDPI Initiatives

Follow MDPI