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Effect of β-caryophyllene from Cloves Extract on Helicobacter pylori Eradication in Mouse Model

1
Department of Internal Medicine, Yonsei University College of Medicine, Seoul 03722, Korea
2
SFC bio Co., Ltd., 119, Dandae-ro, Dongnam-gu, Cheonan-si, Chungnam 31116, Korea
3
New Drug & Bio Research Center, Handok Inc. 2nd floor, A-dong, BioPark, 700, Daewangpangyo-ro, Bundang-gu, Seongnam-si 13488, Korea
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(4), 1000; https://doi.org/10.3390/nu12041000
Received: 6 March 2020 / Revised: 2 April 2020 / Accepted: 2 April 2020 / Published: 4 April 2020
(This article belongs to the Section Phytochemicals and Human Health)
New antibacterial treatments against Helicobacter pylori are needed as H. pylori is acquiring antibiotic resistance. β-caryophyllene is a natural bicyclic sesquiterpene, with anti-inflammatory and antimicrobial effects. This study investigates the effects of H-002119-00-001 from β-caryophyllene on the eradication of H. pylori in a mouse model, and its effects on the inflammation of the gastric mucosa. To evaluate the anti-H.pylori efficacy of β-caryophyllene, a total of 160 mice were divided into eight groups (n = 10 each) and were administered different treatments for 2 and 4 weeks. H. pylori eradication was assessed using a Campylobacter-like organism (CLO) test and H. pylori qPCR of the gastric mucosa. The levels of inflammation of gastric mucosa were assessed using histology and immunostaining. H-002119-00-001 decreased bacterial burden in vitro. When H-002119-00-001 was administered to mice once daily for 2 weeks, cure rates shown by the CLO test were 40.0%, 60.0%, and 70.0% in groups 6, 7, and 8, respectively. H. pylori levels in gastric mucosa decreased dose-dependently after H-002119-00-001 treatment. H-002119-00-001 also reduced levels of inflammation in gastric mucosa. H-002119-00-001 improved inflammation and decreased bacterial burden in H. pylori-infected mouse models. H-002119-00-001 is a promising and effective therapeutic agent for the treatment of H. pylori infection. View Full-Text
Keywords: β-caryophyllene; Helicobacter pylori; eradication β-caryophyllene; Helicobacter pylori; eradication
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MDPI and ACS Style

Jung, D.H.; Park, M.H.; Kim, C.J.; Lee, J.Y.; Keum, C.Y.; Kim, I.S.; Yun, C.-H.; Kim, S.-k.; Kim, W.H.; Lee, Y.C. Effect of β-caryophyllene from Cloves Extract on Helicobacter pylori Eradication in Mouse Model. Nutrients 2020, 12, 1000. https://doi.org/10.3390/nu12041000

AMA Style

Jung DH, Park MH, Kim CJ, Lee JY, Keum CY, Kim IS, Yun C-H, Kim S-k, Kim WH, Lee YC. Effect of β-caryophyllene from Cloves Extract on Helicobacter pylori Eradication in Mouse Model. Nutrients. 2020; 12(4):1000. https://doi.org/10.3390/nu12041000

Chicago/Turabian Style

Jung, Da H., Mi H. Park, Chul J. Kim, Jin Y. Lee, Chang Y. Keum, In S. Kim, Chang-Hyun Yun, Sung-kyu Kim, Won H. Kim, and Yong C. Lee. 2020. "Effect of β-caryophyllene from Cloves Extract on Helicobacter pylori Eradication in Mouse Model" Nutrients 12, no. 4: 1000. https://doi.org/10.3390/nu12041000

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