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Article

Human Milk Oligosaccharide Profile Variation Throughout Postpartum in Healthy Women in a Brazilian Cohort

1
Nutritional Epidemiology Observatory, Department of Social and Applied Nutrition, Institute of Nutrition Josué de Castro, Rio de Janeiro Federal University, Rio de Janeiro 21941-590, Brazil
2
Department of Pediatrics and Mother-Milk-Infant Center of Research Excellence, University of California, San Diego, La Jolla, CA 92161, USA
3
Graduate Program in Nutrition, Institute of Nutrition Josué de Castro, Rio de Janeiro Federal University, Rio de Janeiro 21941-590, Brazil
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(3), 790; https://doi.org/10.3390/nu12030790
Received: 15 February 2020 / Revised: 5 March 2020 / Accepted: 8 March 2020 / Published: 17 March 2020
(This article belongs to the Special Issue Human Milk, HMO, Lactation and Application in Infant Feeding)
Human milk oligosaccharide (HMO) composition varies throughout lactation and can be influenced by maternal characteristics. This study describes HMO variation up to three months postpartum and explores the influences of maternal sociodemographic and anthropometric characteristics in a Brazilian prospective cohort. We followed 101 subjects from 28–35 gestational weeks (baseline) and throughout lactation at 2–8 (visit 1), 28–50 (visit 2) and 88–119 days postpartum (visit 3). Milk samples were collected at visits 1, 2 and 3, and 19 HMOs were quantified usinghigh-performance liquid chromatography with fluorescence detection (HPLC-FL). Friedman post-hoc test, Spearman rank correlation for maternal characteristics and HMOs and non-negative matrix factorization (NMF) were used to define the HMO profile. Most women were secretors (89.1%) and presented high proportion of 2′-fucosyllactose (2′FL) at all three sample times, while lacto-N-tetraose (LNT, 2–8 days) and lacto-N-fucopentaose II (LNFPII, 28–50 and 88–119 days) were the most abundant HMOs in non-secretor women. Over the course of lactation, total HMO weight concentrations (g/L) decreased, but total HMO molar concentrations (mmol/L) increased, highlighting differential changes in HMO composition over time. In addition, maternal pre-pregnancy body mass index (BMI) and parity influence the HMO composition in healthy women in this Brazilian cohort. View Full-Text
Keywords: human milk oligosaccharides; secretor; lactation; human milk composition; body mass index; HPLC; sialyllactose; fucosyllactose human milk oligosaccharides; secretor; lactation; human milk composition; body mass index; HPLC; sialyllactose; fucosyllactose
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MDPI and ACS Style

Ferreira, A.L.; Alves, R.; Figueiredo, A.; Alves-Santos, N.; Freitas-Costa, N.; Batalha, M.; Yonemitsu, C.; Manivong, N.; Furst, A.; Bode, L.; Kac, G. Human Milk Oligosaccharide Profile Variation Throughout Postpartum in Healthy Women in a Brazilian Cohort. Nutrients 2020, 12, 790. https://doi.org/10.3390/nu12030790

AMA Style

Ferreira AL, Alves R, Figueiredo A, Alves-Santos N, Freitas-Costa N, Batalha M, Yonemitsu C, Manivong N, Furst A, Bode L, Kac G. Human Milk Oligosaccharide Profile Variation Throughout Postpartum in Healthy Women in a Brazilian Cohort. Nutrients. 2020; 12(3):790. https://doi.org/10.3390/nu12030790

Chicago/Turabian Style

Ferreira, Ana L., Ronaldo Alves, Amanda Figueiredo, Nadya Alves-Santos, Nathalia Freitas-Costa, Mônica Batalha, Chloe Yonemitsu, Nadia Manivong, Annalee Furst, Lars Bode, and Gilberto Kac. 2020. "Human Milk Oligosaccharide Profile Variation Throughout Postpartum in Healthy Women in a Brazilian Cohort" Nutrients 12, no. 3: 790. https://doi.org/10.3390/nu12030790

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