Next Article in Journal
Nutrient Extraction Lowers Postprandial Glucose Response of Fruit in Adults with Obesity as well as Healthy Weight Adults
Next Article in Special Issue
Nutrition and the Immune System: A Complicated Tango
Previous Article in Journal
Prevalence of Zinc Deficiency in Japanese Patients on Peritoneal Dialysis: Comparative Study in Patients on Hemodialysis
Previous Article in Special Issue
Physical Activity and Diet Shape the Immune System during Aging
Article

Plasma Levels of the Bioactive Sphingolipid Metabolite S1P in Adult Cystic Fibrosis Patients: Potential Target for Immunonutrition?

1
Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria
2
Institute of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090 Vienna, Austria
3
Institute of Nutritional Science, Faculty of Mathematics and Natural Science, University of Potsdam, 14558 Nuthetal, Germany
4
Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 1090 Vienna, Austria
5
Division of Thoracic Surgery, Department of Surgery, Medical University of Vienna, 1090 Vienna, Austria
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(3), 765; https://doi.org/10.3390/nu12030765
Received: 17 January 2020 / Revised: 5 March 2020 / Accepted: 11 March 2020 / Published: 14 March 2020
(This article belongs to the Special Issue Immunomodulation and Nutrition)
Recent research has linked sphingolipid (SL) metabolism with cystic fibrosis transmembrane conductance regulator (CFTR) activity, affecting bioactive lipid mediator sphingosine-1-phosphate (S1P). We hypothesize that loss of CFTR function in cystic fibrosis (CF) patients influenced plasma S1P levels. Total and unbound plasma S1P levels were measured in 20 lung-transplanted adult CF patients and 20 healthy controls by mass spectrometry and enzyme-linked immunosorbent assay (ELISA). S1P levels were correlated with CFTR genotype, routine laboratory parameters, lung function and pathogen colonization, and clinical symptoms. Compared to controls, CF patients showed lower unbound plasma S1P, whereas total S1P levels did not differ. A positive correlation of total and unbound S1P levels was found in healthy controls, but not in CF patients. Higher unbound S1P levels were measured in ΔF508-homozygous compared to ΔF508-heterozygous CF patients (p = 0.038), accompanied by higher levels of HDL in ΔF508-heterozygous patients. Gastrointestinal symptoms were more common in ΔF508 heterozygotes compared to ΔF508 homozygotes. This is the first clinical study linking plasma S1P levels with CFTR function and clinical presentation in adult CF patients. Given the emerging role of immunonutrition in CF, our study might pave the way for using S1P as a novel biomarker and nutritional target in CF. View Full-Text
Keywords: sphingolipids; sphingosine-1-phosphate; intestine; high density lipoproteins; cystic fibrosis; ΔF508 mutation; immunonutrition sphingolipids; sphingosine-1-phosphate; intestine; high density lipoproteins; cystic fibrosis; ΔF508 mutation; immunonutrition
Show Figures

Figure 1

MDPI and ACS Style

Halilbasic, E.; Fuerst, E.; Heiden, D.; Japtok, L.; Diesner, S.C.; Trauner, M.; Kulu, A.; Jaksch, P.; Hoetzenecker, K.; Kleuser, B.; Kazemi-Shirazi, L.; Untersmayr, E. Plasma Levels of the Bioactive Sphingolipid Metabolite S1P in Adult Cystic Fibrosis Patients: Potential Target for Immunonutrition? Nutrients 2020, 12, 765. https://doi.org/10.3390/nu12030765

AMA Style

Halilbasic E, Fuerst E, Heiden D, Japtok L, Diesner SC, Trauner M, Kulu A, Jaksch P, Hoetzenecker K, Kleuser B, Kazemi-Shirazi L, Untersmayr E. Plasma Levels of the Bioactive Sphingolipid Metabolite S1P in Adult Cystic Fibrosis Patients: Potential Target for Immunonutrition? Nutrients. 2020; 12(3):765. https://doi.org/10.3390/nu12030765

Chicago/Turabian Style

Halilbasic, Emina, Elisabeth Fuerst, Denise Heiden, Lukasz Japtok, Susanne C. Diesner, Michael Trauner, Askin Kulu, Peter Jaksch, Konrad Hoetzenecker, Burkhard Kleuser, Lili Kazemi-Shirazi, and Eva Untersmayr. 2020. "Plasma Levels of the Bioactive Sphingolipid Metabolite S1P in Adult Cystic Fibrosis Patients: Potential Target for Immunonutrition?" Nutrients 12, no. 3: 765. https://doi.org/10.3390/nu12030765

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop