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The Gut Microbiota and Its Implication in the Development of Atherosclerosis and Related Cardiovascular Diseases

1
Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, 18071 Granada, Spain
2
Institute of Nutrition and Food Technology “José Mataix”, Center of Biomedical Research, University of Granada, Avda. del Conocimiento s/n., 18016 Armilla, Granada, Spain
3
Instituto de Investigación Biosanitaria IBS.GRANADA, Complejo Hospitalario Universitario de Granada, 18014 Granada, Spain
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Department of Nutrition, Exercise and Sports (NEXS), Section of Integrative Physiology, University of Copenhagen, Nørre Allé 51, DK-2200 Copenhagen, Denmark
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Departamento de Farmacia, Facultad de Química, Pontificia Universidad Católica de Chile, Santiago 6094411, Chile
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National Agency for Medicines (ANAMED), Public Health Institute, Santiago 7780050, Chile
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Cardiology Unit, Hospital Universitario Virgen de la Nieves, 18014 Granada, Spain
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Department of Cell Biology, School of Sciences, University of Granada, 18071 Granada, Spain
*
Authors to whom correspondence should be addressed.
Nutrients 2020, 12(3), 605; https://doi.org/10.3390/nu12030605
Received: 25 January 2020 / Revised: 19 February 2020 / Accepted: 21 February 2020 / Published: 26 February 2020
(This article belongs to the Special Issue Nutrition, Microbiota and Noncommunicable Diseases)
The importance of gut microbiota in health and disease is being highlighted by numerous research groups worldwide. Atherosclerosis, the leading cause of heart disease and stroke, is responsible for about 50% of all cardiovascular deaths. Recently, gut dysbiosis has been identified as a remarkable factor to be considered in the pathogenesis of cardiovascular diseases (CVDs). In this review, we briefly discuss how external factors such as dietary and physical activity habits influence host-microbiota and atherogenesis, the potential mechanisms of the influence of gut microbiota in host blood pressure and the alterations in the prevalence of those bacterial genera affecting vascular tone and the development of hypertension. We will also be examining the microbiota as a therapeutic target in the prevention of CVDs and the beneficial mechanisms of probiotic administration related to cardiovascular risks. All these new insights might lead to novel analysis and CVD therapeutics based on the microbiota. View Full-Text
Keywords: cardiovascular diseases; atherosclerosis; gut microbiota; microbiome cardiovascular diseases; atherosclerosis; gut microbiota; microbiome
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MDPI and ACS Style

Sanchez-Rodriguez, E.; Egea-Zorrilla, A.; Plaza-Díaz, J.; Aragón-Vela, J.; Muñoz-Quezada, S.; Tercedor-Sánchez, L.; Abadia-Molina, F. The Gut Microbiota and Its Implication in the Development of Atherosclerosis and Related Cardiovascular Diseases. Nutrients 2020, 12, 605. https://doi.org/10.3390/nu12030605

AMA Style

Sanchez-Rodriguez E, Egea-Zorrilla A, Plaza-Díaz J, Aragón-Vela J, Muñoz-Quezada S, Tercedor-Sánchez L, Abadia-Molina F. The Gut Microbiota and Its Implication in the Development of Atherosclerosis and Related Cardiovascular Diseases. Nutrients. 2020; 12(3):605. https://doi.org/10.3390/nu12030605

Chicago/Turabian Style

Sanchez-Rodriguez, Estefania, Alejandro Egea-Zorrilla, Julio Plaza-Díaz, Jerónimo Aragón-Vela, Sergio Muñoz-Quezada, Luis Tercedor-Sánchez, and Francisco Abadia-Molina. 2020. "The Gut Microbiota and Its Implication in the Development of Atherosclerosis and Related Cardiovascular Diseases" Nutrients 12, no. 3: 605. https://doi.org/10.3390/nu12030605

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