Next Article in Journal
Taste Changes in Patients with Inflammatory Bowel Disease: Associations with PROP Phenotypes and polymorphisms in the salivary protein, Gustin and CD36 Receptor Genes
Next Article in Special Issue
Feeding the Outer Bran Fraction of Rice Alters Hepatic Carbohydrate Metabolism in Rats
Previous Article in Journal
Consumption of Lactose, Other FODMAPs and Diarrhoea during Adjuvant 5-Fluorouracil Chemotherapy for Colorectal Cancer
Previous Article in Special Issue
DHA-Induced Perturbation of Human Serum Metabolome. Role of the Food Matrix and Co-Administration of Oat β-glucan and Anthocyanins
 
Search for Articles:
Title / Keyword
Author / Affiliation
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
Journals
Nutrients
Volume 12
Issue 2
10.3390/nu12020408
nutrients-logo
Submit to this Journal Review for this Journal Edit a Special Issue
► Article Menu

Article Menu

share announcement question_answer thumb_up
...
textsms
...
Article

Beneficial Effects of a Low-dose of Conjugated Linoleic Acid on Body Weight Gain and other Cardiometabolic Risk Factors in Cafeteria Diet-fed Rats

by
Miguel Z Martín-González
1,†,
Héctor Palacios
1,2,†,
Miguel A Rodríguez
2,
Lluís Arola
1,3,
Gerard Aragonès
1,* and
Begoña Muguerza
1
1
Department of Biochemistry and Biotechnology, Nutrigenomics Research Group, Universitat Rovira i Virgili, 43007 Tarragona, Spain
2
Eurecat, Centre Tecnològic de Catalunya, Centre for Omic Sciences (COS), Joint Unit Universitat Rovira i Virgili-EURECAT, Unique Scientific and Technical Infrastructures (ICTS), 43204 Reus, Spain
3
Eurecat, Centre Tecnològic de Catalunya, Biotechnological Area, 43204 Reus, Spain
*
Author to whom correspondence should be addressed.
†
Both authors contributed equally to this manuscript.
Nutrients 2020, 12(2), 408; https://doi.org/10.3390/nu12020408
Received: 15 January 2020 / Revised: 28 January 2020 / Accepted: 2 February 2020 / Published: 4 February 2020
(This article belongs to the Special Issue Metabolomics in Nutrition and Human Health)
View Full-Text Download PDF
Browse Figures

Abstract

Conjugated linoleic acid (CLA) is a dietary supplement that has been shown to improve obesity. However, some authors have associated high doses of CLA supplementation with liver impairment and insulin resistance. The aim of this study was to assess whether the consumption of low doses of CLA maintained the beneficial effects on the main metabolic disturbances associated with metabolic syndrome (MetS) but prevented the occurrence of non-desirable outcomes associated with its consumption. Male Wistar rats, fed standard or cafeteria (CAF) diet for 12 weeks, were supplemented with three different low doses of CLA in the last three weeks. Both biochemical and H1 NMR-based metabolomics profiles were analysed in serum and liver. The consumption of 100 mg/kg CLA, but not doses of 200 and 300 mg/kg, ameliorated the increase in body weight gain as well as the serum concentrations of glucose, insulin, cholesterol, triglyceride, diglyceride, and total phospholipid induced by a CAF diet. In turn, CLA reverted the increase in lactate, alanine, and glucose concentrations in the liver of these animals, but enhanced hepatic cholesterol accumulation without any detrimental effect on liver function. In conclusion, a low dose of CLA corrected the adverse effects associated with MetS without compromising other metabolic parameters. View Full-Text
Keywords: CLA; insulin resistance; leptin; metabolomics; NAFLD; obesity CLA; insulin resistance; leptin; metabolomics; NAFLD; obesity
►▼ Show Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Supplementary Material

SciFeed

Share and Cite

MDPI and ACS Style

Martín-González, M.Z.; Palacios, H.; Rodríguez, M.A.; Arola, L.; Aragonès, G.; Muguerza, B. Beneficial Effects of a Low-dose of Conjugated Linoleic Acid on Body Weight Gain and other Cardiometabolic Risk Factors in Cafeteria Diet-fed Rats. Nutrients 2020, 12, 408. https://doi.org/10.3390/nu12020408

AMA Style

Martín-González MZ, Palacios H, Rodríguez MA, Arola L, Aragonès G, Muguerza B. Beneficial Effects of a Low-dose of Conjugated Linoleic Acid on Body Weight Gain and other Cardiometabolic Risk Factors in Cafeteria Diet-fed Rats. Nutrients. 2020; 12(2):408. https://doi.org/10.3390/nu12020408

Chicago/Turabian Style

Martín-González, Miguel Z., Héctor Palacios, Miguel A. Rodríguez, Lluís Arola, Gerard Aragonès, and Begoña Muguerza. 2020. "Beneficial Effects of a Low-dose of Conjugated Linoleic Acid on Body Weight Gain and other Cardiometabolic Risk Factors in Cafeteria Diet-fed Rats" Nutrients 12, no. 2: 408. https://doi.org/10.3390/nu12020408

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Map by Country/Region

1
Back to TopTop