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Open AccessArticle

Feeding the Outer Bran Fraction of Rice Alters Hepatic Carbohydrate Metabolism in Rats

1
Department of Biochemical Science and Technology, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan
2
Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan
3
Shokkyo Co., Ltd., 5-9 Matsukawacho, Minami-ku, Hiroshima 732-0826, Japan
*
Author to whom correspondence should be addressed.
contribute equally to this study.
Nutrients 2020, 12(2), 430; https://doi.org/10.3390/nu12020430
Received: 23 December 2019 / Revised: 27 January 2020 / Accepted: 5 February 2020 / Published: 7 February 2020
(This article belongs to the Special Issue Metabolomics in Nutrition and Human Health)
Dietary intake of fiber-rich food has been reported to contribute to multiple health benefits. The aim of the current study is to investigate the effects of a diet containing the outer bran fraction of rice (OBFR), which is rich in insoluble fiber, on the intestinal environment and metabolite profiles of rats. Fourteen 8-week-old male Sprague–Dawley rats were divided into a control group and an OBFR group. For a period of 21 days, the control group was fed a control diet, while the OBFR group was fed a diet containing 5% OBFR. Metabolomics analysis revealed drastic changes in the cecal metabolites of the rats fed the OBFR diet. Furthermore, in the plasma and liver tissue, the concentrations of metabolites involved in pyruvate metabolism, the pentose phosphate pathway, gluconeogenesis, or valine, leucine, isoleucine degradation were changed. Concordantly, the OBFR diet increased the expression of genes encoding enzymes involved in these metabolic pathways in the livers of the rats. Collectively, these results suggest that the OBFR diet altered the concentrations of metabolites in the cecal contents, plasma, and liver, and the hepatic gene expressions of rats, and that this may have mainly contributed to carbohydrate metabolism in the liver.
Keywords: metabolomics; rice bran; short-chain fatty acid; fatty acid synthesis; gluconeogenesis metabolomics; rice bran; short-chain fatty acid; fatty acid synthesis; gluconeogenesis
MDPI and ACS Style

Kawaguchi, M.; Nishikoba, N.; Shimamoto, S.; Tomonaga, S.; Kohrogi, R.; Yamauchi, Y.; Fujita, Y.; Ohtsuka, A.; Ijiri, D. Feeding the Outer Bran Fraction of Rice Alters Hepatic Carbohydrate Metabolism in Rats. Nutrients 2020, 12, 430.

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