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Open AccessArticle

The Impact of Coconut Oil and Epigallocatechin Gallate on the Levels of IL-6, Anxiety and Disability in Multiple Sclerosis Patients

1
Doctoral Degree School, Catholic University of Valencia San Vicente Martir, 46001 Valencia, Spain
2
Department of Nursing, Catholic University of Valencia San Vicente Martir, 46001 Valencia, Spain
3
Department of Nursing, Physiotherapy and Medicine, University of Almería, 04120 Almería, Spain
4
Department of Physical Activity and Sport Sciences, Catholic University of Valencia San Vicente Martir, 46001 Valencia, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(2), 305; https://doi.org/10.3390/nu12020305
Received: 19 December 2019 / Revised: 15 January 2020 / Accepted: 19 January 2020 / Published: 23 January 2020
(This article belongs to the Special Issue Nutrition and Fitness: Mental Health)
Background: Due to the inflammatory nature of multiple sclerosis (MS), interleukin 6 (IL-6) is high in blood levels, and it also increases the levels of anxiety related to functional disability. Epigallocatechin gallate (EGCG) decreases IL-6, which could be enhanced by the anti-inflammatory effect of high ketone bodies after administering coconut oil (both of which are an anxiolytic). Therefore, the aim of this study was to assess the impact of coconut oil and EGCG on the levels of IL-6, anxiety and functional disability in patients with MS. Methods: A pilot study was conducted for four months with 51 MS patients who were randomly divided into an intervention group and a control group. The intervention group received 800 mg of EGCG and 60 mL of coconut oil, and the control group was prescribed a placebo. Both groups followed the same isocaloric Mediterranean diet. State and trait anxiety were determined before and after the study by means of the State-Trait Anxiety Inventory (STAI). In addition, IL-6 in serum was measured using the ELISA technique and functional capacity was determined with the Expanded Disability Status Scale (EDSS) and the body mass index (BMI). Results: State anxiety and functional capacity decreased in the intervention group and IL-6 decreased in both groups. Conclusions: EGCG and coconut oil improve state anxiety and functional capacity. In addition, a decrease in IL-6 is observed in patients with MS, possibly due to the antioxidant capacity of the Mediterranean diet and its impact on improving BMI. View Full-Text
Keywords: multiple sclerosis; epigallocatechin gallate; coconut oil; interleukin-6; anxiety; disability multiple sclerosis; epigallocatechin gallate; coconut oil; interleukin-6; anxiety; disability
MDPI and ACS Style

Platero, J.L.; Cuerda-Ballester, M.; Ibáñez, V.; Sancho, D.; Lopez-Rodríguez, M.M.; Drehmer, E.; de la Rubia Ortí, J.E. The Impact of Coconut Oil and Epigallocatechin Gallate on the Levels of IL-6, Anxiety and Disability in Multiple Sclerosis Patients. Nutrients 2020, 12, 305. https://doi.org/10.3390/nu12020305

AMA Style

Platero JL, Cuerda-Ballester M, Ibáñez V, Sancho D, Lopez-Rodríguez MM, Drehmer E, de la Rubia Ortí JE. The Impact of Coconut Oil and Epigallocatechin Gallate on the Levels of IL-6, Anxiety and Disability in Multiple Sclerosis Patients. Nutrients. 2020; 12(2):305. https://doi.org/10.3390/nu12020305

Chicago/Turabian Style

Platero, Jose L.; Cuerda-Ballester, María; Ibáñez, Vanessa; Sancho, David; Lopez-Rodríguez, María M.; Drehmer, Eraci; de la Rubia Ortí, Jose E. 2020. "The Impact of Coconut Oil and Epigallocatechin Gallate on the Levels of IL-6, Anxiety and Disability in Multiple Sclerosis Patients" Nutrients 12, no. 2: 305. https://doi.org/10.3390/nu12020305

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