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Nutrients
Volume 12
Issue 2
10.3390/nu12020284
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Review

Current Knowledge about the Effect of Nutritional Status, Supplemented Nutrition Diet, and Gut Microbiota on Hepatic Ischemia-Reperfusion and Regeneration in Liver Surgery

by
María Eugenia Cornide-Petronio
1,†,
Ana Isabel Álvarez-Mercado
2,3,4,†,
Mónica B. Jiménez-Castro
1,‡ and
Carmen Peralta
1,5,*,‡
1
Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain
2
Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, 18071 Granada, Spain
3
Institute of Nutrition and Food Technology “José Mataix,” Center of Biomedical Research, University of Granada, Avda. del Conocimiento s/n, 18016 Armilla, Granada, Spain
4
Instituto de Investigación Biosanitaria ibs, GRANADA, Complejo Hospitalario Universitario de Granada, 18014 Granada, Spain
5
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 08036 Barcelona, Spain
*
Author to whom correspondence should be addressed.
†
These authors equally contributed to this work.
‡
These authors equally contributed to this work.
Nutrients 2020, 12(2), 284; https://doi.org/10.3390/nu12020284
Submission received: 19 November 2019 / Revised: 13 January 2020 / Accepted: 15 January 2020 / Published: 21 January 2020
(This article belongs to the Special Issue Nutrition, Microbiota and Noncommunicable Diseases)
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Abstract

Ischemia-reperfusion (I/R) injury is an unresolved problem in liver resection and transplantation. The preexisting nutritional status related to the gut microbial profile might contribute to primary non-function after surgery. Clinical studies evaluating artificial nutrition in liver resection are limited. The optimal nutritional regimen to support regeneration has not yet been exactly defined. However, overnutrition and specific diet factors are crucial for the nonalcoholic or nonalcoholic steatohepatitis liver diseases. Gut-derived microbial products and the activation of innate immunity system and inflammatory response, leading to exacerbation of I/R injury or impaired regeneration after resection. This review summarizes the role of starvation, supplemented nutrition diet, nutritional status, and alterations in microbiota on hepatic I/R and regeneration. We discuss the most updated effects of nutritional interventions, their ability to alter microbiota, some of the controversies, and the suitability of these interventions as potential therapeutic strategies in hepatic resection and transplantation, overall highlighting the relevance of considering the extended criteria liver grafts in the translational liver surgery.
Keywords: ischemia-reperfusion injury; nutritional status; supplemented nutrition; gut microbiota; partial hepatectomy; liver transplantation ischemia-reperfusion injury; nutritional status; supplemented nutrition; gut microbiota; partial hepatectomy; liver transplantation

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MDPI and ACS Style

Cornide-Petronio, M.E.; Álvarez-Mercado, A.I.; Jiménez-Castro, M.B.; Peralta, C. Current Knowledge about the Effect of Nutritional Status, Supplemented Nutrition Diet, and Gut Microbiota on Hepatic Ischemia-Reperfusion and Regeneration in Liver Surgery. Nutrients 2020, 12, 284. https://doi.org/10.3390/nu12020284

AMA Style

Cornide-Petronio ME, Álvarez-Mercado AI, Jiménez-Castro MB, Peralta C. Current Knowledge about the Effect of Nutritional Status, Supplemented Nutrition Diet, and Gut Microbiota on Hepatic Ischemia-Reperfusion and Regeneration in Liver Surgery. Nutrients. 2020; 12(2):284. https://doi.org/10.3390/nu12020284

Chicago/Turabian Style

Cornide-Petronio, María Eugenia, Ana Isabel Álvarez-Mercado, Mónica B. Jiménez-Castro, and Carmen Peralta. 2020. "Current Knowledge about the Effect of Nutritional Status, Supplemented Nutrition Diet, and Gut Microbiota on Hepatic Ischemia-Reperfusion and Regeneration in Liver Surgery" Nutrients 12, no. 2: 284. https://doi.org/10.3390/nu12020284

APA Style

Cornide-Petronio, M. E., Álvarez-Mercado, A. I., Jiménez-Castro, M. B., & Peralta, C. (2020). Current Knowledge about the Effect of Nutritional Status, Supplemented Nutrition Diet, and Gut Microbiota on Hepatic Ischemia-Reperfusion and Regeneration in Liver Surgery. Nutrients, 12(2), 284. https://doi.org/10.3390/nu12020284

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