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Open AccessArticle

Circulatory and Urinary B-Vitamin Responses to Multivitamin Supplement Ingestion Differ between Older and Younger Adults

1
The Liggins Institute, University of Auckland, Auckland 1023, New Zealand
2
Riddet Institute, Palmerston North 4474, New Zealand
3
Food & Bio-based Products Group, AgResearch, Palmerston North 4442, New Zealand
4
High-Value Nutrition National Science Challenge, Auckland 1023, New Zealand
5
Department of Human Nutrition, University of Otago, Dunedin 9016, New Zealand
6
Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, Singapore 117609, Singapore
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(11), 3529; https://doi.org/10.3390/nu12113529
Received: 23 October 2020 / Revised: 10 November 2020 / Accepted: 13 November 2020 / Published: 17 November 2020
(This article belongs to the Special Issue Dietary Supplements and Human Health)
Multivitamin and mineral (MVM) supplements are frequently used amongst older populations to improve adequacy of micronutrients, including B-vitamins, but evidence for improved health outcomes are limited and deficiencies remain prevalent. Although this may indicate poor efficacy of supplements, this could also suggest the possibility for altered B-vitamin bioavailability and metabolism in older people. This open-label, single-arm acute parallel study, conducted at the Liggins Institute Clinical Research Unit in Auckland, compared circulatory and urinary B-vitamer responses to MVM supplementation in older (70.1 ± 2.7 y, n = 10 male, n = 10 female) compared to younger (24.2 ± 2.8 y, n = 10 male, n = 10 female) participants for 4 h after the ingestion of a single dose of a commercial MVM supplement and standardized breakfast. Older adults had a lower area under the curve (AUC) of postprandial plasma pyridoxine (p = 0.02) and pyridoxal-5′phosphate (p = 0.03) forms of vitamin B6 but greater 4-pyridoxic acid AUC (p = 0.009). Urinary pyridoxine and pyridoxal excretion were higher in younger females than in older females (time × age × sex interaction, p < 0.05). Older adults had a greater AUC increase in plasma thiamine (p = 0.01), riboflavin (p = 0.009), and pantothenic acid (p = 0.027). In older adults, there was decreased plasma responsiveness of the ingested (pyridoxine) and active (pyridoxal-5′phosphate) forms of vitamin B6, which indicated a previously undescribed alteration in either absorption or subsequent metabolic interconversion. While these findings cannot determine whether acute B6 responsiveness is adequate, this difference may have potential implications for B6 function in older adults. Although this may imply higher B vitamin substrate requirements for older people, further work is required to understand the implications of postprandial differences in availability. View Full-Text
Keywords: B-vitamins supplement; vitamin B6; ageing; B-vitamin bioavailability; ultra-high performance liquid chromatography coupled with mass spectrometry; excretion B-vitamins supplement; vitamin B6; ageing; B-vitamin bioavailability; ultra-high performance liquid chromatography coupled with mass spectrometry; excretion
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MDPI and ACS Style

Sharma, P.; Han, S.M.; Gillies, N.; Thorstensen, E.B.; Goy, M.; Barnett, M.P.G.; Roy, N.C.; Cameron-Smith, D.; Milan, A.M. Circulatory and Urinary B-Vitamin Responses to Multivitamin Supplement Ingestion Differ between Older and Younger Adults. Nutrients 2020, 12, 3529. https://doi.org/10.3390/nu12113529

AMA Style

Sharma P, Han SM, Gillies N, Thorstensen EB, Goy M, Barnett MPG, Roy NC, Cameron-Smith D, Milan AM. Circulatory and Urinary B-Vitamin Responses to Multivitamin Supplement Ingestion Differ between Older and Younger Adults. Nutrients. 2020; 12(11):3529. https://doi.org/10.3390/nu12113529

Chicago/Turabian Style

Sharma, Pankaja; Han, Soo M.; Gillies, Nicola; Thorstensen, Eric B.; Goy, Michael; Barnett, Matthew P.G.; Roy, Nicole C.; Cameron-Smith, David; Milan, Amber M. 2020. "Circulatory and Urinary B-Vitamin Responses to Multivitamin Supplement Ingestion Differ between Older and Younger Adults" Nutrients 12, no. 11: 3529. https://doi.org/10.3390/nu12113529

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