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Fructose, Omega 3 Fatty Acids, and Vitamin E: Involvement in Pediatric Non-Alcoholic Fatty Liver Disease

1
Gastroenterology and Nutrition Department, Division of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago 3580000, Chile
2
Department of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Católica de Chile, Santiago 3580000, Chile
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(11), 3531; https://doi.org/10.3390/nu12113531
Received: 30 September 2020 / Revised: 30 October 2020 / Accepted: 9 November 2020 / Published: 17 November 2020
(This article belongs to the Special Issue Nutrition for Non-Alcoholic Fatty Liver Disease)
Non-alcoholic fatty liver disease (NAFLD) is currently the most common form of liver disease in both adults and children, becoming the leading cause for liver transplant in many countries. Its prevalence has increased considerably in recent years, mainly due to the explosive increase in pediatric obesity rates. NAFLD is strongly associated with central obesity, diabetes, dyslipidemia and insulin resistance, and it has been considered as the hepatic manifestation of the metabolic syndrome. Its complex pathophysiology involves a series of metabolic, inflammatory and oxidative stress processes, among others. Given the sharp increase in the prevalence of NAFLD and the lack of an appropriate pharmacological approach, it is crucial to consider the prevention/management of the disease based on lifestyle modifications such as the adoption of a healthy nutrition pattern. Herein, we review the literature and discuss the role of three key nutrients involved in pediatric NAFLD: fructose and its participation in metabolism, Omega-3 fatty acids and its anti-inflammatory effects and vitamin E and its action on oxidative stress. View Full-Text
Keywords: nonalcoholic fatty liver disease (NAFLD); NASH; nutrition; steatosis; sugar; fructose; omega 3 fatty acids; vitamin E nonalcoholic fatty liver disease (NAFLD); NASH; nutrition; steatosis; sugar; fructose; omega 3 fatty acids; vitamin E
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MDPI and ACS Style

Alberti, G.; Gana, J.C.; Santos, J.L. Fructose, Omega 3 Fatty Acids, and Vitamin E: Involvement in Pediatric Non-Alcoholic Fatty Liver Disease. Nutrients 2020, 12, 3531. https://doi.org/10.3390/nu12113531

AMA Style

Alberti G, Gana JC, Santos JL. Fructose, Omega 3 Fatty Acids, and Vitamin E: Involvement in Pediatric Non-Alcoholic Fatty Liver Disease. Nutrients. 2020; 12(11):3531. https://doi.org/10.3390/nu12113531

Chicago/Turabian Style

Alberti, Gigliola; Gana, Juan C.; Santos, José L. 2020. "Fructose, Omega 3 Fatty Acids, and Vitamin E: Involvement in Pediatric Non-Alcoholic Fatty Liver Disease" Nutrients 12, no. 11: 3531. https://doi.org/10.3390/nu12113531

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