Next Article in Journal
Red for “Stop”: “Traffic-Light” Nutrition Labels Decrease Unhealthy Food Choices by Increasing Activity and Connectivity in the Frontal Lobe
Next Article in Special Issue
Beneficial Effects of Walnuts on Cognition and Brain Health
Previous Article in Journal
Association of Sleep Quality and Macronutrient Distribution: A Systematic Review and Meta-Regression
Previous Article in Special Issue
Associations between Food Group Intake, Cognition, and Academic Achievement in Elementary Schoolchildren
Article

Bariatric Surgery and Brain Health—A Longitudinal Observational Study Investigating the Effect of Surgery on Cognitive Function and Gray Matter Volume

1
Department of Neurology & NeuroCure Clinical Research Center, Charité—Universitätsmedizin Berlin, 10117 Berlin, Germany
2
Department of Psychology, Medical School Hamburg, 20457 Hamburg, Germany
3
Department of Neurology, Aging and Obesity Group, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany
4
Institute of Biometry and Clinical Epidemiology, Charité—Universitätsmedizin Berlin, 10117 Berlin, Germany
5
Berlin Institute of Health, Charité—Universitätsmedizin Berlin, 10117 Berlin, Germany
6
Center for Bariatric and Metabolic Surgery, Charité—Universitätsmedizin Berlin, 10117 Berlin, Germany
7
Center for Bariatric and Metabolic Surgery, Vivantes Klinikum Spandau, 13585 Berlin, Germany
8
Department of Neurology, University of Greifswald, 17489 Greifswald, Germany
9
German Center for Neurodegenerative Diseases, Standort Rostock/Greifswald, 17489 Greifswald, Germany
*
Authors to whom correspondence should be addressed.
Both authors contributed equally to the paper.
Nutrients 2020, 12(1), 127; https://doi.org/10.3390/nu12010127
Received: 15 November 2019 / Revised: 13 December 2019 / Accepted: 28 December 2019 / Published: 2 January 2020
(This article belongs to the Special Issue Dietary Intake, Brain Development and Learning)
Dietary modifications leading to weight loss have been suggested as a means to improve brain health. In morbid obesity, bariatric surgery (BARS)—including different procedures, such as vertical sleeve gastrectomy (VSG), gastric banding (GB), or Roux-en-Y gastric bypass (RYGB) surgery—is performed to induce rapid weight loss. Combining reduced food intake and malabsorption of nutrients, RYGB might be most effective, but requires life-long follow-up treatment. Here, we tested 40 patients before and six months after surgery (BARS group) using a neuropsychological test battery and compared them with a waiting list control group. Subsamples of both groups underwent structural MRI and were examined for differences between surgical procedures. No substantial differences between BARS and control group emerged with regard to cognition. However, larger gray matter volume in fronto-temporal brain areas accompanied by smaller volume in the ventral striatum was seen in the BARS group compared to controls. RYGB patients compared to patients with restrictive treatment alone (VSG/GB) had higher weight loss, but did not benefit more in cognitive outcomes. In sum, the data of our study suggest that BARS might lead to brain structure reorganization at long-term follow-up, while the type of surgical procedure does not differentially modulate cognitive performance. View Full-Text
Keywords: Roux-en-Y gastric bypass; executive functions; voxel-based morphometry; fronto-temporal cortex; nucleus accumbens Roux-en-Y gastric bypass; executive functions; voxel-based morphometry; fronto-temporal cortex; nucleus accumbens
Show Figures

Figure 1

MDPI and ACS Style

Prehn, K.; Profitlich, T.; Rangus, I.; Heßler, S.; Witte, A.V.; Grittner, U.; Ordemann, J.; Flöel, A. Bariatric Surgery and Brain Health—A Longitudinal Observational Study Investigating the Effect of Surgery on Cognitive Function and Gray Matter Volume. Nutrients 2020, 12, 127. https://doi.org/10.3390/nu12010127

AMA Style

Prehn K, Profitlich T, Rangus I, Heßler S, Witte AV, Grittner U, Ordemann J, Flöel A. Bariatric Surgery and Brain Health—A Longitudinal Observational Study Investigating the Effect of Surgery on Cognitive Function and Gray Matter Volume. Nutrients. 2020; 12(1):127. https://doi.org/10.3390/nu12010127

Chicago/Turabian Style

Prehn, Kristin; Profitlich, Thorge; Rangus, Ida; Heßler, Sebastian; Witte, A. V.; Grittner, Ulrike; Ordemann, Jürgen; Flöel, Agnes. 2020. "Bariatric Surgery and Brain Health—A Longitudinal Observational Study Investigating the Effect of Surgery on Cognitive Function and Gray Matter Volume" Nutrients 12, no. 1: 127. https://doi.org/10.3390/nu12010127

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop