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Volume 11
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10.3390/nu11092227
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Article

Interdisciplinary Weight Loss and Lifestyle Intervention for Obstructive Sleep Apnoea in Adults: Rationale, Design and Methodology of the INTERAPNEA Study

by
Almudena Carneiro-Barrera
1,*,
Francisco J. Amaro-Gahete
2,3,
Amparo Díaz-Román
1,
Alejandro Guillén-Riquelme
1,
Lucas Jurado-Fasoli
2,3,
Germán Sáez-Roca
4,
Carlos Martín-Carrasco
4,
Jonatan R. Ruiz
3 and
Gualberto Buela-Casal
1
1
Sleep and Health Promotion Laboratory, Mind, Brain and Behaviour Research Centre (CIMCYC), University of Granada, 18011 Granada, Spain
2
EFFECTS-262 Research group, Department of Medical Physiology, School of Medicine, University of Granada, 18071 Granada, Spain
3
PROmoting FITness and Health through physical activity research group (PROFITH), Sport and Health University Research Institute (iMUDS), Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, 18071 Granada, Spain
4
Unidad de Trastornos Respiratorios del Sueño, Servicio de Neumología, “Virgen de las Nieves” University Hospital, 18014 Granada, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(9), 2227; https://doi.org/10.3390/nu11092227
Submission received: 30 July 2019 / Revised: 9 September 2019 / Accepted: 11 September 2019 / Published: 15 September 2019
(This article belongs to the Special Issue Sleep, Nutrition, and Human Health)
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Abstract

Obesity is a major risk factor for obstructive sleep apnoea (OSA), the most common sleep-disordered breathing related to neurocognitive and metabolic syndromes, type II diabetes, and cardiovascular diseases. Although strongly recommended for this condition, there are no studies on the effectiveness of an interdisciplinary weight loss and lifestyle intervention including nutrition, exercise, sleep hygiene, and smoking and alcohol cessation. INTERAPNEA is a randomised controlled trial with a two-arm parallel design aimed at determining the effects of an interdisciplinary tailored weight loss and lifestyle intervention on OSA outcomes. The study will include 84 males aged 18–65 with a body mass index of ≥25 kg/m2 and severe to moderate OSA randomly assigned to usual care (i.e., continuous positive airway pressure), or interdisciplinary weight loss and lifestyle intervention combined with usual care. Outcomes will be measured at baseline, intervention end-point, and six-month post-intervention, including apnoea-hypopnoea index (primary outcome), other neurophysical and cardiorespiratory polysomnographic outcomes, sleep quality, daily functioning and mood, body weight and composition, physical fitness, blood biomarkers, health-related quality of life, and cost-effectiveness. INTERAPNEA may serve to establish a cost-effective treatment not only for the improvement of OSA and its vast and severe comorbidities, but also for a potential remission of this condition.
Keywords: obstructive sleep apnoea; apnoea-hypopnoea index; obesity; weight loss; interdisciplinary lifestyle intervention; nutrition; exercise; sleep hygiene; smoking; alcohol obstructive sleep apnoea; apnoea-hypopnoea index; obesity; weight loss; interdisciplinary lifestyle intervention; nutrition; exercise; sleep hygiene; smoking; alcohol

Share and Cite

MDPI and ACS Style

Carneiro-Barrera, A.; Amaro-Gahete, F.J.; Díaz-Román, A.; Guillén-Riquelme, A.; Jurado-Fasoli, L.; Sáez-Roca, G.; Martín-Carrasco, C.; Ruiz, J.R.; Buela-Casal, G. Interdisciplinary Weight Loss and Lifestyle Intervention for Obstructive Sleep Apnoea in Adults: Rationale, Design and Methodology of the INTERAPNEA Study. Nutrients 2019, 11, 2227. https://doi.org/10.3390/nu11092227

AMA Style

Carneiro-Barrera A, Amaro-Gahete FJ, Díaz-Román A, Guillén-Riquelme A, Jurado-Fasoli L, Sáez-Roca G, Martín-Carrasco C, Ruiz JR, Buela-Casal G. Interdisciplinary Weight Loss and Lifestyle Intervention for Obstructive Sleep Apnoea in Adults: Rationale, Design and Methodology of the INTERAPNEA Study. Nutrients. 2019; 11(9):2227. https://doi.org/10.3390/nu11092227

Chicago/Turabian Style

Carneiro-Barrera, Almudena, Francisco J. Amaro-Gahete, Amparo Díaz-Román, Alejandro Guillén-Riquelme, Lucas Jurado-Fasoli, Germán Sáez-Roca, Carlos Martín-Carrasco, Jonatan R. Ruiz, and Gualberto Buela-Casal. 2019. "Interdisciplinary Weight Loss and Lifestyle Intervention for Obstructive Sleep Apnoea in Adults: Rationale, Design and Methodology of the INTERAPNEA Study" Nutrients 11, no. 9: 2227. https://doi.org/10.3390/nu11092227

APA Style

Carneiro-Barrera, A., Amaro-Gahete, F. J., Díaz-Román, A., Guillén-Riquelme, A., Jurado-Fasoli, L., Sáez-Roca, G., Martín-Carrasco, C., Ruiz, J. R., & Buela-Casal, G. (2019). Interdisciplinary Weight Loss and Lifestyle Intervention for Obstructive Sleep Apnoea in Adults: Rationale, Design and Methodology of the INTERAPNEA Study. Nutrients, 11(9), 2227. https://doi.org/10.3390/nu11092227

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