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Article

Baru Almonds Increase the Activity of Glutathione Peroxidase in Overweight and Obese Women: A Randomized, Placebo-Controlled Trial

1
Clinical and Sports Nutrition Research Laboratory (LABINCE), Faculty of Nutrition, Federal University of Goias—UFG, Goiânia, 74605-080 GO, Brazil
2
Department of Health Sciences; Faculty of Medicine, University of São Paulo—USP, Ribeirão Preto, 14049-900 SP, Brazil
3
Nucleus of Toxic-pharmacological Studies and Research (NEPET), Federal University of Goiás—UFG, Goiânia, 74605-220 GO, Brazil
4
Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo—FCRP/USP, Ribeirão Preto, 14040-903 SP, Brazil
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(8), 1750; https://doi.org/10.3390/nu11081750
Received: 6 June 2019 / Revised: 20 July 2019 / Accepted: 26 July 2019 / Published: 30 July 2019
(This article belongs to the Special Issue Nuts Intake and Human Health)
Background: Obesity-induced inflammation is frequently associated with higher oxidative stress. In vitro and experimental studies have considered baru almonds (Dipteryx alata Vog) as a legume seed with high antioxidant capacity. The aim of this study was to evaluate whether baru almonds are capable of improving the inflammatory and antioxidant status in overweight and obese women. Methods: In a parallel-arm, randomized placebo-controlled trial, 46 overweight and obese women (age: 40 ± 11 years; body mass index: 33.3 ± 4.3) were randomly assigned to receive advice to follow a normocaloric and isoenergetic diet with placebo (PLA, n = 22) or similar advice plus 20 g baru almonds (BARU, n = 24) for 8 wk. Malondialdehyde (MDA), adiponectin, tumor necrosis factor-α, interleukin-6, interleukin-10, antioxidant enzymes activities (catalase—CAT; glutathione peroxidase—GPx; superoxide dismutase—SOD), and minerals were analyzed in plasma samples. Results: At baseline, groups were similar regarding the body composition, oxidative, and inflammatory parameters. The BARU group increased the activity of GPx (+0.08 U/mg, 95%CI + 0.05 to +0.12 vs. −0.07, 95%CI −0.12 to −0.03, p < 0.01) and plasma copper concentration (p = 0.037) when compared to the PLA group. No differences were observed between groups in CAT and SOD activity or MDA and cytokines concentrations. Conclusions: Baru almond supplementation increased the GPx activity in overweight and obese women. View Full-Text
Keywords: nuts; oxidative stress; overweight; inflammation; minerals nuts; oxidative stress; overweight; inflammation; minerals
MDPI and ACS Style

de Souza, R.G.M.; Gomes, A.C.; Navarro, A.M.; Cunha, L.C.d.; Silva, M.A.C.; Junior, F.B.; Mota, J.F. Baru Almonds Increase the Activity of Glutathione Peroxidase in Overweight and Obese Women: A Randomized, Placebo-Controlled Trial. Nutrients 2019, 11, 1750. https://doi.org/10.3390/nu11081750

AMA Style

de Souza RGM, Gomes AC, Navarro AM, Cunha LCd, Silva MAC, Junior FB, Mota JF. Baru Almonds Increase the Activity of Glutathione Peroxidase in Overweight and Obese Women: A Randomized, Placebo-Controlled Trial. Nutrients. 2019; 11(8):1750. https://doi.org/10.3390/nu11081750

Chicago/Turabian Style

de Souza, Rávila G.M., Aline C. Gomes, Anderson M. Navarro, Luiz C.d. Cunha, Marina A.C. Silva, Fernando B. Junior, and João F. Mota. 2019. "Baru Almonds Increase the Activity of Glutathione Peroxidase in Overweight and Obese Women: A Randomized, Placebo-Controlled Trial" Nutrients 11, no. 8: 1750. https://doi.org/10.3390/nu11081750

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