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The Impact of Pectin Supplementation on Intestinal Barrier Function in Healthy Young Adults and Healthy Elderly

1
Division Gastroenterology-Hepatology, Department of Internal Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, 6202 AZ Maastricht, The Netherlands
2
Top Institute Food and Nutrition, 6700 AN Wageningen, The Netherlands
3
Cell Biology and Immunology Group, Department of Animal Sciences, Wageningen University, 6708 WD Wageningen, The Netherlands
4
Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, 6200 MD Maastricht, The Netherlands
5
Department of Pathology and Medical Biology, Section Immunoendocrinology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands
6
Department of Food Innovation and Health, Centre for Healthy Eating and Food Innovation, Maastricht University, 5911 AA Venlo, The Netherlands
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(7), 1554; https://doi.org/10.3390/nu11071554
Received: 14 June 2019 / Revised: 1 July 2019 / Accepted: 8 July 2019 / Published: 9 July 2019
(This article belongs to the Special Issue Dietary Fiber and Human Health)
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Abstract

Intestinal barrier function is suggested to decrease with aging and may be improved by pectin intake. The aim of this study was to investigate the effects of four weeks pectin supplementation on gastrointestinal barrier function in vivo and ex vivo in different age groups. In a randomized, double-blind, placebo-controlled, parallel study, 52 healthy young adults (18–40 years) and 48 healthy elderly (65–75 years) received 15 g/day pectin or placebo for four weeks. Pre- and post-intervention, in vivo gastrointestinal permeability by a multisugar test, and defense capacity in mucosal samples were assessed. Sigmoid biopsies were collected post-intervention from subgroups for Ussing chamber experiments and gene transcription of barrier-related genes. Pectin intervention did not affect in vivo gastroduodenal, small intestinal, colonic, and whole gut permeability in young adults nor in elderly (p ≥ 0.130). Salivary and fecal sIgA and serum IgA were not significantly different between pectin versus placebo in both age groups (p ≥ 0.128). In both young adults and elderly, no differences in transepithelial electrical resistance and fluorescein flux (p ≥ 0.164) and relative expression of genes analyzed (p ≥ 0.222) were found between pectin versus placebo. In conclusion, intestinal barrier function was not affected by four weeks pectin supplementation neither in healthy young adults nor in healthy elderly. View Full-Text
Keywords: aging; dietary fiber; intestinal permeability; tight junctions; defense; gastrointestinal; tolerance aging; dietary fiber; intestinal permeability; tight junctions; defense; gastrointestinal; tolerance
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Wilms, E.; Jonkers, D.M.; Savelkoul, H.F.; Elizalde, M.; Tischmann, L.; de Vos, P.; Masclee, A.A.; Troost, F.J. The Impact of Pectin Supplementation on Intestinal Barrier Function in Healthy Young Adults and Healthy Elderly. Nutrients 2019, 11, 1554.

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