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Open AccessArticle

Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study

1
Escuela de Nutrición y Dietética, Facultad de Medicina, Universidad Andres Bello, Sede Concepción 4260000, Chile
2
Facultad de Ciencias de la Salud, Universidad Simón Bolívar, Barranquilla 080003, Colombia
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Centro de Investigaciones Endocrino-Metabólicas “Dr. Félix Gómez”, Escuela de Medicina. Facultad de Medicina, Universidad del Zulia, Maracaibo 4001, Venezuela
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Departamento de Medicina Física y Rehabilitación, Hospital “12 de Octubre”, Madrid 28041, Spain
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Escuela de Nutrición y Dietética, Facultad de Ciencias para el Cuidado de la Salud, Universidad San Sebastián, Santiago 7500000, Chile
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Escuela de Salud, Universidad Tecnológica de Chile, INACAP, Sede Concepción, Talcahuano 4260000, Chile
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Faculty of Medicine/UniFAGOC, Ubá 36506-022, Minas Gerais, Brazil
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Universidade do Estado de Minas Gerais (UEMG), Barbacena 36202-284, Minas Gerais, Brazil
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Escuela de Nutrición y Dietética, Facultad de Medicina, Universidad Andres Bello, Santiago 8370321, Chile
10
Lipids and Atherosclerosis Unit, Maimonides Institute for Biomedical Research in Cordoba, Reina Sofia University Hospital, University of Córdoba, 14004 Córdoba, Spain
11
CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III, 28029 Madrid, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(7), 1477; https://doi.org/10.3390/nu11071477
Received: 19 April 2019 / Revised: 21 June 2019 / Accepted: 24 June 2019 / Published: 28 June 2019
(This article belongs to the Special Issue Dietary Intake and Type 2 Diabetes)
Oral diabetes-specific nutritional supplements (ONS-D) induce favourable postprandial responses in subjects with type 2 diabetes (DM2), but they have not been correlated yet with incretin release and subjective appetite (SA). This randomised, double-blind, cross-over study compared postprandial effects of ONS-D with isomaltulose and sucromalt versus standard formula (ET) on glycaemic index (GI), insulin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1) and SA in 16 individuals with DM2. After overnight fasting, subjects consumed a portion of supplements containing 25 g of carbohydrates or reference food. Blood samples were collected at baseline and at 30, 60, 90, 120, 150 and 180 min; and SA sensations were assessed by a visual analogue scale on separate days. Glycaemic index values were low for ONS-D and intermediate for ET (p < 0.001). The insulin area under the curve (AUC0–180 min) (p < 0.02) and GIP AUC (p < 0.02) were lower after ONS-D and higher GLP-1 AUC when compared with ET (p < 0.05). Subjective appetite AUC was greater after ET than ONS-D (p < 0.05). Interactions between hormones, hunger, fullness and GI were found, but not within the ratings of SA; isomaltulose and sucromalt may have influenced these factors. View Full-Text
Keywords: glycaemic index; incretins; subjective appetite; isomaltulose; sucromalt; nutritional supplement glycaemic index; incretins; subjective appetite; isomaltulose; sucromalt; nutritional supplement
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Angarita Dávila, L.; Bermúdez, V.; Aparicio, D.; Céspedes, V.; Escobar, M.C.; Durán-Agüero, S.; Cisternas, S.; de Assis Costa, J.; Rojas-Gómez, D.; Reyna, N.; López-Miranda, J. Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study. Nutrients 2019, 11, 1477.

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