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Nutrients
Volume 11
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10.3390/nu11051190
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Article

Cyanidin-3-O-Galactoside-Enriched Aronia melanocarpa Extract Attenuates Weight Gain and Adipogenic Pathways in High-Fat Diet-Induced Obese C57BL/6 Mice

by
Su-Min Lim
1,†,
Hyun Sook Lee
2,†,
Jae In Jung
1,
So Mi Kim
1,
Nam Young Kim
3,
Tae Su Seo
3,
Jung-Shik Bae
3 and
Eun Ji Kim
1,*
1
Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University, Chuncheon, Gangwon 24252, Korea
2
Department of Food Science & Nutrition, Dongseo University, Busan 47011, Korea
3
R&D center, Wellfine Co., Ltd., Chuncheon, Gangwon 24232, Korea
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Nutrients 2019, 11(5), 1190; https://doi.org/10.3390/nu11051190
Submission received: 5 April 2019 / Revised: 16 May 2019 / Accepted: 23 May 2019 / Published: 27 May 2019
(This article belongs to the Special Issue Dietary Bioactive Compounds and Human Health and Disease)
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Abstract

Aronia melanocarpa are a rich source of anthocyanins that have received considerable interest for their relations to human health. In this study, the anti-adipogenic effect of cyanidin-3-O-galactoside-enriched Aronia melanocarpa extract (AM-Ex) and its underlying mechanisms were investigated in an in vivo system. Five-week-old male C57BL/6N mice were randomly divided into five groups for 8-week feeding with a control diet (CD), a high-fat diet (HFD), or a HFD with 50 (AM-Ex 50), 100 (AM-Ex 100), or 200 AM-Ex (AM-Ex 200) mg/kg body weight/day. HFD-fed mice showed a significant increase in body weight compared to the CD group, and AM-Ex dose-dependently inhibited this weight gain. AM-Ex significantly reduced the food intake and the weight of white fat tissue, including epididymal fat, retroperitoneal fat, mesenteric fat, and inguinal fat. Treatment with AM-Ex (50 to 200 mg/kg) reduced serum levels of leptin, insulin, triglyceride, total cholesterol, and low density lipoprotein (LDL)-cholesterol. Real-time reverse transcription-polymerase chain reaction (RT-PCR) analysis revealed that AM-Ex suppressed adipogenesis by decreasing CCAAT/enhancer binding protein α, peroxisome proliferator-activated receptor γ, sterol regulatory element-binding protein-1c, peroxisome proliferator-activated receptor gamma coactivator-1α, acetyl-CoA carboxylase 1, ATP-citrate lyase, fatty acid synthase, and adipocyte protein 2 messenger RNA (mRNA) expressions. These results suggest that AM-Ex is potentially beneficial for the suppression of HFD-induced obesity by modulating multiple pathways associated with adipogenesis and food intake.
Keywords: Aronia melanocarpa; cyanidin-3-O-galactoside; adipogenesis; adipogenic transcription factor; high fat induced obesity Aronia melanocarpa; cyanidin-3-O-galactoside; adipogenesis; adipogenic transcription factor; high fat induced obesity

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MDPI and ACS Style

Lim, S.-M.; Lee, H.S.; Jung, J.I.; Kim, S.M.; Kim, N.Y.; Seo, T.S.; Bae, J.-S.; Kim, E.J. Cyanidin-3-O-Galactoside-Enriched Aronia melanocarpa Extract Attenuates Weight Gain and Adipogenic Pathways in High-Fat Diet-Induced Obese C57BL/6 Mice. Nutrients 2019, 11, 1190. https://doi.org/10.3390/nu11051190

AMA Style

Lim S-M, Lee HS, Jung JI, Kim SM, Kim NY, Seo TS, Bae J-S, Kim EJ. Cyanidin-3-O-Galactoside-Enriched Aronia melanocarpa Extract Attenuates Weight Gain and Adipogenic Pathways in High-Fat Diet-Induced Obese C57BL/6 Mice. Nutrients. 2019; 11(5):1190. https://doi.org/10.3390/nu11051190

Chicago/Turabian Style

Lim, Su-Min, Hyun Sook Lee, Jae In Jung, So Mi Kim, Nam Young Kim, Tae Su Seo, Jung-Shik Bae, and Eun Ji Kim. 2019. "Cyanidin-3-O-Galactoside-Enriched Aronia melanocarpa Extract Attenuates Weight Gain and Adipogenic Pathways in High-Fat Diet-Induced Obese C57BL/6 Mice" Nutrients 11, no. 5: 1190. https://doi.org/10.3390/nu11051190

APA Style

Lim, S.-M., Lee, H. S., Jung, J. I., Kim, S. M., Kim, N. Y., Seo, T. S., Bae, J.-S., & Kim, E. J. (2019). Cyanidin-3-O-Galactoside-Enriched Aronia melanocarpa Extract Attenuates Weight Gain and Adipogenic Pathways in High-Fat Diet-Induced Obese C57BL/6 Mice. Nutrients, 11(5), 1190. https://doi.org/10.3390/nu11051190

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