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Health Benefits of Resveratrol in Kidney Disease: Evidence from In Vitro and In Vivo Studies

1
Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada
2
Centre for Bone and Muscle Health, Brock University, St. Catharines, ON L2S 3A1, Canada
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(7), 1624; https://doi.org/10.3390/nu11071624
Received: 30 May 2019 / Revised: 5 July 2019 / Accepted: 10 July 2019 / Published: 17 July 2019
(This article belongs to the Special Issue Dietary Bioactive Compounds and Human Health and Disease)
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PDF [1301 KB, uploaded 17 July 2019]
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Abstract

Different diseases and disorders that affect the kidneys include, but are not limited to, glomerulonephritis, diabetic nephropathy, polycystic kidney disease, kidney stones, renal fibrosis, sepsis, and renal cell carcinoma. Kidney disease tends to develop over many years, making it difficult to identify until much later when kidney function is severely impaired and undergoing kidney failure. Although conservative care, symptom management, medication, dialysis, transplantation, and aggressive renal cancer therapy are some of the current strategies/approaches to kidney disease treatment, new preventative targeted therapies are needed. Epidemiological studies have suggested that a diet rich in fruits and vegetables is associated with health benefits including protection against kidney disease and renal cancer. Resveratrol, a polyphenol found in grapes and berries, has been reported to have antioxidant, anti-inflammatory, antidiabetic, hepatoprotective, neuroprotective, and anti-cancer properties. The current review summarizes the existing in vitro and in vivo animal and human studies examining the nephroprotective effects of resveratrol. View Full-Text
Keywords: resveratrol; kidney disease; mesangial cells; renal epithelial cells; fibroblasts; glomerulosclerosis; renal cancer resveratrol; kidney disease; mesangial cells; renal epithelial cells; fibroblasts; glomerulosclerosis; renal cancer
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Den Hartogh, D.J.; Tsiani, E. Health Benefits of Resveratrol in Kidney Disease: Evidence from In Vitro and In Vivo Studies. Nutrients 2019, 11, 1624.

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