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Open AccessArticle

γ-Oryzanol Improves Cognitive Function and Modulates Hippocampal Proteome in Mice

1
Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy
2
Institut für Biochemie und Molekularbiologie, Universität Bonn, 53115 Bonn, Germany
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(4), 753; https://doi.org/10.3390/nu11040753
Received: 7 March 2019 / Revised: 27 March 2019 / Accepted: 28 March 2019 / Published: 31 March 2019
(This article belongs to the Special Issue Dietary Bioactives and Human Health)
Rice (Oryza sativa L.) is the richest source of γ-oryzanol, a compound endowed with antioxidant and anti-inflammatory properties. γ-Oryzanol has been demonstrated to cross the blood-brain barrier in intact form and exert beneficial effects on brain function. This study aimed to clarify the effects of γ-oryzanol in the hippocampus in terms of cognitive function and protein expression. Adult mice were administered with γ-oryzanol 100 mg/kg or vehicle (control) once a day for 21 consecutive days following which cognitive behavior and hippocampal proteome were investigated. Cognitive tests using novel object recognition and Y-maze showed that long-term consumption of γ-oryzanol improves cognitive function in mice. To investigate the hippocampal proteome modulated by γ-oryzanol, 2D-difference gel electrophoresis (2D-DIGE) was performed. Interestingly, we found that γ-oryzanol modulates quantitative changes of proteins involved in synaptic plasticity and neuronal trafficking, neuroprotection and antioxidant activity, and mitochondria and energy metabolism. These findings suggested γ-oryzanol as a natural compound able to maintain and reinforce brain function. Although more intensive studies are needed, we propose γ-oryzanol as a putative dietary phytochemical for preserving brain reserve, the ability to tolerate age-related changes, thereby preventing clinical symptoms or signs of neurodegenerative diseases. View Full-Text
Keywords: γ-oryzanol; cognitive function; brain; hippocampus; behavior; antioxidant; proteomics; Oryza sativa γ-oryzanol; cognitive function; brain; hippocampus; behavior; antioxidant; proteomics; Oryza sativa
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MDPI and ACS Style

Rungratanawanich, W.; Cenini, G.; Mastinu, A.; Sylvester, M.; Wilkening, A.; Abate, G.; Bonini, S.A.; Aria, F.; Marziano, M.; Maccarinelli, G.; Memo, M.; Voos, W.; Uberti, D. γ-Oryzanol Improves Cognitive Function and Modulates Hippocampal Proteome in Mice. Nutrients 2019, 11, 753. https://doi.org/10.3390/nu11040753

AMA Style

Rungratanawanich W, Cenini G, Mastinu A, Sylvester M, Wilkening A, Abate G, Bonini SA, Aria F, Marziano M, Maccarinelli G, Memo M, Voos W, Uberti D. γ-Oryzanol Improves Cognitive Function and Modulates Hippocampal Proteome in Mice. Nutrients. 2019; 11(4):753. https://doi.org/10.3390/nu11040753

Chicago/Turabian Style

Rungratanawanich, Wiramon; Cenini, Giovanna; Mastinu, Andrea; Sylvester, Marc; Wilkening, Anne; Abate, Giulia; Bonini, Sara A.; Aria, Francesca; Marziano, Mariagrazia; Maccarinelli, Giuseppina; Memo, Maurizio; Voos, Wolfgang; Uberti, Daniela. 2019. "γ-Oryzanol Improves Cognitive Function and Modulates Hippocampal Proteome in Mice" Nutrients 11, no. 4: 753. https://doi.org/10.3390/nu11040753

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