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Open AccessArticle

β-Cryptoxanthin Reduces Body Fat and Increases Oxidative Stress Response in Caenorhabditis elegans Model

1
Cell Biology Laboratory, Food Biotechnology Department, Biópolis SL/Archer Daniels Midland, C/Catedrático Agustín Escardino Benlloch 9, Paterna, 46890 Valencia, Spain
2
Food Biotechnology Department, Instituto de Agroquímica y Tecnología de Alimentos (IATA), Consejo Superior de Investigaciones Científicas (CSIC), C/Catedrático Agustín Escardino 7, Paterna, 46890 Valencia, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2019, 11(2), 232; https://doi.org/10.3390/nu11020232
Received: 12 November 2018 / Revised: 17 December 2018 / Accepted: 15 January 2019 / Published: 22 January 2019
(This article belongs to the Special Issue Carotenoids and Human Health)
β-Cryptoxanthin (BCX) is a major dietary pro-vitamin A carotenoid, found mainly in fruits and vegetables. Several studies showed the beneficial effects of BCX on different aspects of human health. In spite of the evidence, the molecular mechanisms of action of BCX need to be further investigated. The Caenorhabditis elegans model was used to analyze in vivo the activity of BCX on fat reduction and protection to oxidative stress. Dose-response assays provided evidence of the efficacy of BCX at very low dose (0.025 µg/mL) (p < 0.001) on these processes. Moreover, a comparative analysis with other carotenoids, such as lycopene and β-carotene, showed a stronger effect of BCX. Furthermore, a transcriptomic analysis of wild-type nematodes supplemented with BCX revealed upregulation of the energy metabolism, response to stress, and protein homeostasis as the main metabolic targets of this xanthophyll. Collectively, this study provides new in vivo evidence of the potential therapeutic use of BCX in the prevention of diseases related to metabolic syndrome and aging. View Full-Text
Keywords: β-Cryptoxanthin; carotenoids; Caenorhabditis elegans; fat reduction; oxidative stress; transcriptomic analysis; metabolic syndrome; aging β-Cryptoxanthin; carotenoids; Caenorhabditis elegans; fat reduction; oxidative stress; transcriptomic analysis; metabolic syndrome; aging
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Llopis, S.; Rodrigo, M.J.; González, N.; Genovés, S.; Zacarías, L.; Ramón, D.; Martorell, P. β-Cryptoxanthin Reduces Body Fat and Increases Oxidative Stress Response in Caenorhabditis elegans Model. Nutrients 2019, 11, 232.

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