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Open AccessArticle

Differential Responses of Blood Essential Amino Acid Levels Following Ingestion of High-Quality Plant-Based Protein Blends Compared to Whey Protein—A Double-Blind Randomized, Cross-Over, Clinical Trial

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Danone North America, Louisville, CO 80027, USA
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Sequel Naturals, Burnaby, BC V5G 4W3, Canada
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Excelya, 92100 Boulogne-Billancourt, France
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Danone Research, 91120 Palaiseau, France
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Danone North America, White Plains, NY 10605, USA
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Author to whom correspondence should be addressed.
Nutrients 2019, 11(12), 2987; https://doi.org/10.3390/nu11122987
Received: 14 November 2019 / Revised: 3 December 2019 / Accepted: 4 December 2019 / Published: 6 December 2019
(This article belongs to the Section Clinical Nutrition)
This study assessed the bio-equivalence of high-quality, plant-based protein blends versus Whey Protein Isolate (WPI) in healthy, resistance-trained men. The primary endpoint was incremental area under the curve (iAUC) of blood essential Amino Acids (eAAs) 4 hours after consumption of each product. Maximum concentration (Cmax) and time to maximum concentration (Tmax) of blood leucine were secondary outcomes. Subjects (n = 18) consumed three plant-based protein blends and WPI (control). An analysis of Variance model was used to assess for bio-equivalence of total sum of blood eAA concentrations. The total blood eAA iAUC ratios of the three blends were [90% CI]: #1: 0.66 [0.58–0.76]; #2: 0.71 [0.62–0.82]; #3: 0.60 [0.52–0.69], not completely within the pre-defined equivalence range [0.80–1.25], indicative of 30–40% lower iAUC versus WPI. Leucine Cmax of the three blends was not equivalent to WPI, #1: 0.70 [0.67–0.73]; #2: 0.72 [0.68–0.75]; #3: 0.65 [0.62–0.68], indicative of a 28–35% lower response. Leucine Tmax for two blends were similar to WPI (#1: 0.94 [0.73–1.18]; #2: 1.56 [1.28–1.92]; #3: 1.19 [0.95–1.48]). The plant-based protein blends were not bio-equivalent. However, blood leucine kinetic data across the blends approximately doubled from fasting concentrations, whereas blood Tmax data across two blends were similar to WPI. This suggests evidence of rapid hyperleucinemia, which correlates with a protein’s anabolic potential. View Full-Text
Keywords: protein; plant-based protein; whey protein; essential amino acids; leucine; healthy men protein; plant-based protein; whey protein; essential amino acids; leucine; healthy men
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MDPI and ACS Style

Brennan, J.L.; Keerati-u-rai, M.; Yin, H.; Daoust, J.; Nonnotte, E.; Quinquis, L.; St-Denis, T.; Bolster, D.R. Differential Responses of Blood Essential Amino Acid Levels Following Ingestion of High-Quality Plant-Based Protein Blends Compared to Whey Protein—A Double-Blind Randomized, Cross-Over, Clinical Trial. Nutrients 2019, 11, 2987. https://doi.org/10.3390/nu11122987

AMA Style

Brennan JL, Keerati-u-rai M, Yin H, Daoust J, Nonnotte E, Quinquis L, St-Denis T, Bolster DR. Differential Responses of Blood Essential Amino Acid Levels Following Ingestion of High-Quality Plant-Based Protein Blends Compared to Whey Protein—A Double-Blind Randomized, Cross-Over, Clinical Trial. Nutrients. 2019; 11(12):2987. https://doi.org/10.3390/nu11122987

Chicago/Turabian Style

Brennan, Jessica L.; Keerati-u-rai, Maneephan; Yin, Huaixia; Daoust, Julie; Nonnotte, Emilie; Quinquis, Laurent; St-Denis, Thierry; Bolster, Douglas R. 2019. "Differential Responses of Blood Essential Amino Acid Levels Following Ingestion of High-Quality Plant-Based Protein Blends Compared to Whey Protein—A Double-Blind Randomized, Cross-Over, Clinical Trial" Nutrients 11, no. 12: 2987. https://doi.org/10.3390/nu11122987

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