Next Article in Journal
Impact of Bean Consumption on Nutritional Outcomes amongst Adolescents
Next Article in Special Issue
Effect of Lactobacillus acidophilus Fermented Broths Enriched with Eruca sativa Seed Extracts on Intestinal Barrier and Inflammation in a Co-Culture System of an Enterohemorrhagic Escherichia coli and Human Intestinal Cells
Previous Article in Journal
Gut Microbiome, Intestinal Permeability, and Tissue Bacteria in Metabolic Disease: Perpetrators or Bystanders?
Previous Article in Special Issue
Herbal Medicines Attenuate PD-L1 Expression to Induce Anti-Proliferation in Obesity-Related Cancers
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Nutrients
Volume 12
Issue 4
10.3390/nu12041084
nutrients-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Extra-Virgin Olive Oil from Apulian Cultivars and Intestinal Inflammation

by
Marica Cariello
1,
Annalisa Contursi
2,
Raffaella Maria Gadaleta
1,
Elena Piccinin
1,
Stefania De Santis
3,
Marilidia Piglionica
1,
Ada Fiorenza Spaziante
4,
Carlo Sabbà
1,
Gaetano Villani
4 and
Antonio Moschetta
1,5,6,*
1
Clinica Medica Cesare Frugoni, Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, Italy
2
Department of Neuroscience, Imaging, and Clinical Sciences and Center for Research on Aging and Translational Medicine, “G. d’Annunzio” University School of Medicine, 66100 Chieti, Italy
3
Department of Pharmacy-Drug Science, University of Bari “Aldo Moro”, 70126 Bari, Italy
4
Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari “Aldo Moro”, 70124 Bari, Italy
5
INBB, National Institute for Biostructures and Biosystems, 00136 Rome, Italy
6
IRCCS Istituto Tumori Giovanni Paolo II, 70124 Bari, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(4), 1084; https://doi.org/10.3390/nu12041084
Submission received: 19 March 2020 / Revised: 7 April 2020 / Accepted: 11 April 2020 / Published: 14 April 2020
(This article belongs to the Special Issue Nutrition and Apoptosis)
Browse Figures
Versions Notes

Abstract

Inflammatory bowel disease (IBD) is a multifactorial intestinal disorder characterized by chronic intestinal inflammation. The etiology of IBD is still unclear, although genetic, environmental and host factors have been associated to the disease. Extra-virgin olive oil (EVO) is a central component of the Mediterranean diet and it decreases chronic inflammation by interfering with arachidonic acid and NF-κB signaling pathways. Specifically, the different components of EVO are able to confer advantages in terms of health in their site of action. For instance, oleic acid displays a protective effect in liver dysfunction and gut inflammation, whereas phenolic compounds protect colon cells against oxidative damage and improve the symptoms of chronic inflammation in IBD. Given the biological properties of EVO, we investigated whether its administration is able to confer protection in a mouse model of dextrane sodium sulfate (DSS)-induced colitis. Four EVO cultivars from the Apulian Region of Italy, namely Ogliarola (Cima di Bitonto), Coratina, Peranzana and Cima di Mola, respectively, were used. Administration of EVO resulted in reduced body weight loss in our colitis model. Furthermore, mice treated with Ogliarola, Coratina and Cima di Mola EVO displayed a reduction of rectal bleeding and IL-1β, TGFβ, IL-6 gene expression levels. Furthermore, Ogliarola, Coratina and Peranzana EVO administration ameliorated intestinal permeability and histopathological features of inflammation. Our data further validate the well-known positive effects of EVO supplementation in promoting human health and suggest the bona fide contribution of EVO in preventing onset and reducing progression of intestinal inflammation.
Keywords: olive oil; inflammatory bowel disease; intestinal inflammation; animal experimentation; mouse model olive oil; inflammatory bowel disease; intestinal inflammation; animal experimentation; mouse model

Share and Cite

MDPI and ACS Style

Cariello, M.; Contursi, A.; Gadaleta, R.M.; Piccinin, E.; De Santis, S.; Piglionica, M.; Spaziante, A.F.; Sabbà, C.; Villani, G.; Moschetta, A. Extra-Virgin Olive Oil from Apulian Cultivars and Intestinal Inflammation. Nutrients 2020, 12, 1084. https://doi.org/10.3390/nu12041084

AMA Style

Cariello M, Contursi A, Gadaleta RM, Piccinin E, De Santis S, Piglionica M, Spaziante AF, Sabbà C, Villani G, Moschetta A. Extra-Virgin Olive Oil from Apulian Cultivars and Intestinal Inflammation. Nutrients. 2020; 12(4):1084. https://doi.org/10.3390/nu12041084

Chicago/Turabian Style

Cariello, Marica, Annalisa Contursi, Raffaella Maria Gadaleta, Elena Piccinin, Stefania De Santis, Marilidia Piglionica, Ada Fiorenza Spaziante, Carlo Sabbà, Gaetano Villani, and Antonio Moschetta. 2020. "Extra-Virgin Olive Oil from Apulian Cultivars and Intestinal Inflammation" Nutrients 12, no. 4: 1084. https://doi.org/10.3390/nu12041084

APA Style

Cariello, M., Contursi, A., Gadaleta, R. M., Piccinin, E., De Santis, S., Piglionica, M., Spaziante, A. F., Sabbà, C., Villani, G., & Moschetta, A. (2020). Extra-Virgin Olive Oil from Apulian Cultivars and Intestinal Inflammation. Nutrients, 12(4), 1084. https://doi.org/10.3390/nu12041084

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop