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Fat and Sugar—A Dangerous Duet. A Comparative Review on Metabolic Remodeling in Rodent Models of Nonalcoholic Fatty Liver Disease

1
Nencki Institute of Experimental Biology of Polish Academy of Sciences, 02-093 Warsaw, Poland
2
Institute of Toxicology and Environmental Hygiene, Technical University Munich, School of Medicine, Biedersteiner Strasse 29, D-80802 Munich, Germany
3
Department of Pathology, The Children’s Memorial Health Institute, 04-730 Warsaw, Poland
4
Department of General, Transplant and Liver Surgery, Medical University of Warsaw, 02-091 Warsaw, Poland
5
Department of Interventional Radiology and Neuroradiology, Medical University of Lublin, 20-090 Lublin, Poland
6
Laboratory of Metabolic Liver Diseases, Department of General, Transplant and Liver Surgery, Laboratory of Metabolic Liver Diseases, Centre for Preclinical Research, Medical University of Warsaw, 02-091 Warsaw, Poland
7
Department of Medicine II, Saarland University Medical Center, 66421 Homburg, Germany
8
Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, D-85764 Neuherberg, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally and should be considered joint first authors
These authors contributed equally and should be considered joint senior authors
Nutrients 2019, 11(12), 2871; https://doi.org/10.3390/nu11122871
Received: 29 October 2019 / Revised: 20 November 2019 / Accepted: 21 November 2019 / Published: 24 November 2019
Nonalcoholic fatty liver disease (NAFLD) is a common disease in Western society and ranges from steatosis to steatohepatitis to end-stage liver disease such as cirrhosis and hepatocellular carcinoma. The molecular mechanisms that are involved in the progression of steatosis to more severe liver damage in patients are not fully understood. A deeper investigation of NAFLD pathogenesis is possible due to the many different animal models developed recently. In this review, we present a comparative overview of the most common dietary NAFLD rodent models with respect to their metabolic phenotype and morphological manifestation. Moreover, we describe similarities and controversies concerning the effect of NAFLD-inducing diets on mitochondria as well as mitochondria-derived oxidative stress in the progression of NAFLD.
Keywords: mitochondria; NAFLD-inducing diets; nonalcoholic fatty liver disease; oxidative stress mitochondria; NAFLD-inducing diets; nonalcoholic fatty liver disease; oxidative stress
MDPI and ACS Style

Simoes, I.C.; Janikiewicz, J.; Bauer, J.; Karkucinska-Wieckowska, A.; Kalinowski, P.; Dobrzyń, A.; Wolski, A.; Pronicki, M.; Zieniewicz, K.; Dobrzyń, P.; Krawczyk, M.; Zischka, H.; Wieckowski, M.R.; Potes, Y. Fat and Sugar—A Dangerous Duet. A Comparative Review on Metabolic Remodeling in Rodent Models of Nonalcoholic Fatty Liver Disease. Nutrients 2019, 11, 2871.

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