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Article

Hypovitaminosis D in Postherpetic Neuralgia—High Prevalence and Inverse Association with Pain: A Retrospective Study

1
Department of Anesthesiology, Chi Mei Medical Center, Tainan 71004, Taiwan
2
Department of the Senior Citizen Service Management, Chia Nan University of Pharmacy and Science, Tainan 71004, Taiwan
3
Department of Medical Research, Chi Mei Medical Center, Tainan 71004, Taiwan
4
Department of neurology, Chi Mei Medical Center, Tainan 71004, Taiwan
5
The center for General Education, Southern Taiwan University of Science and Technology, Tainan 71004, Taiwan
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(11), 2787; https://doi.org/10.3390/nu11112787
Received: 23 October 2019 / Revised: 7 November 2019 / Accepted: 13 November 2019 / Published: 15 November 2019
(This article belongs to the Special Issue Calcium, Vitamin D and Health)
Hypovitaminosis D (25-hydroxyvitamin D (25(OH)D) <75 nmol/L) is associated with neuropathic pain and varicella-zoster virus (VZV) immunity. A two-part retrospective hospital-based study was conducted. Part I (a case-control study): To investigate the prevalence and risk of hypovitaminosis D in postherpetic neuralgia (PHN) patients compared to those in gender/index-month/age-auto matched controls who underwent health examinations. Patients aged ≥50 years were automatically selected by ICD-9 codes for shingle/PHN. Charts were reviewed. Part II (a cross-sectional study): To determine associations between 25(OH)D, VZV IgG/M, pain and items in the DN4 questionnaire at the first pain clinic visit of patients. Independent predictors of PHN were presented as adjusted odds ratios(AOR) and 95% confidence intervals (CI). Prevalence (73.9%) of hypovitaminosis D in 88 patients was high. In conditional logistic regressions, independent predictors for PHN were hypovitaminosis D (AOR3.12, 95% CI1.73–5.61), malignancy (AOR3.21, 95% CI 1.38–7.48) and Helicobacter pylori-related peptic ulcer disease (AOR3.47, 95% CI 1.71–7.03). 25(OH)D was inversely correlated to spontaneous/brush-evoked pain. Spontaneous pain was positively correlated to VZV IgM. Based on the receiver operator characteristic curve, cutoffs for 25(OH)D to predict spontaneous and brush-evoked pain were 67.0 and 169.0 nmol/L, respectively. A prospective, longitudinal study is needed to elucidate the findings. View Full-Text
Keywords: hypovitaminosis D; 25-hydroxyvitamin D; postherpetic neuralgia; spontaneous pain; brush-evoked pain; varicella-zoster virus immunoglobulin; DN4questionnaire hypovitaminosis D; 25-hydroxyvitamin D; postherpetic neuralgia; spontaneous pain; brush-evoked pain; varicella-zoster virus immunoglobulin; DN4questionnaire
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MDPI and ACS Style

Chen, J.-Y.; Lin, Y.-T.; Wang, L.-K.; Hung, K.-C.; Lan, K.-M.; Ho, C.-H.; Chang, C.-Y. Hypovitaminosis D in Postherpetic Neuralgia—High Prevalence and Inverse Association with Pain: A Retrospective Study. Nutrients 2019, 11, 2787. https://doi.org/10.3390/nu11112787

AMA Style

Chen J-Y, Lin Y-T, Wang L-K, Hung K-C, Lan K-M, Ho C-H, Chang C-Y. Hypovitaminosis D in Postherpetic Neuralgia—High Prevalence and Inverse Association with Pain: A Retrospective Study. Nutrients. 2019; 11(11):2787. https://doi.org/10.3390/nu11112787

Chicago/Turabian Style

Chen, Jen-Yin, Yao-Tsung Lin, Li-Kai Wang, Kuo-Chuan Hung, Kuo-Mao Lan, Chung-Han Ho, and Chia-Yu Chang. 2019. "Hypovitaminosis D in Postherpetic Neuralgia—High Prevalence and Inverse Association with Pain: A Retrospective Study" Nutrients 11, no. 11: 2787. https://doi.org/10.3390/nu11112787

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